Hepatic Cell News Volume 5.25 | Jul 9 2021

    By
    Justin.choi
    -
    0
    45







    2021-07-09 | HCN 5.25


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.25 – 9 July, 2021
    TOP STORY

    Liver-Fibrosis-Activated Transcriptional Networks Govern Hepatocyte Reprogramming and Intra-hepatic Communication

    Using cell-type-resolved genomics, scientists showed that comprehensive alterations in hepatocyte genomic and transcriptional settings during non-alcoholic steatohepatitis progression, led to a loss of hepatocyte identity.
    [Cell Metabolism]

    AbstractGraphical Abstract

    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Adenine Base Editing Reduces Misfolded Protein Accumulation and Toxicity in Alpha-1 Antitrypsin Deficient Patient iPSC-Hepatocytes

    Investigators applied adenine base editors to correct the Z mutation in patient-induced pluripotent stem cells (iPSCs) and iPSC-derived hepatocytes.
    [Molecular Therapy]

    AbstractFull ArticleGraphical Abstract

    Compensatory Hepatic Adaptation Accompanies Permanent Absence of Intrahepatic Biliary Network Due to YAP1 Loss in Liver Progenitors

    Researchers detected Yes-associated protein 1 (YAP1) activity in biliary cells and in cells at the hepatobiliary bifurcation in single-cell RNA sequencing analysis of developing livers
    [Cell Reports]

    Full ArticleGraphical Abstract

    Periostin Deficiency Reduces DEN-Induced Liver Cancer in Mice by Decreasing HSC Activation and Cancer Cell Proliferation

    Scientists demonstrated that periostin was markedly upregulated in diethylnitrosamine (DEN)-induced mouse hepatocellular carcinoma tissues (HCC) and periostin knockout impaired DEN-induced HCC development.
    [Journal of Pathology]

    Abstract

    Green Synthesis of Gold Nanoparticles from Dendrobium officinale and Its Anticancer Effect on Liver Cancer

    In order to evaluate the anti-tumor efficiency and biosafety, the inhibitory rate of HepG2 cells and survival rate of L02 cells were performed in vitro, and the immunohistochemical analysis of H&E, Ki-67, and TUNEL staining were conducted in vivo.
    [Drug Delivery]

    Full Article

    Exosomes Secreted by Palmitic Acid-Treated Hepatocytes Promote LX-2 Cell Activation by Transferring miRNA-107

    Scientists explored the role of exosomes derived from palmitic acid -treated hepatocytes in regulating hepatic stellate cells (LX-2 cell) proliferation and activation and the underlying mechanisms.
    [Cell Death Discovery]

    Abstract

    Implication of Human Endogenous Retrovirus W Family Envelope in Hepatocellular Carcinoma Promotes MEK/ERK-Mediated Metastatic Invasiveness and Doxorubicin Resistance

    There is no report on the expression pattern and potential mechanism of Syncytin-1 in hepatocellular carcinoma (HCC). Functional experiments in vitro and in vivo demonstrated that Syncytin-1 enhanced cell proliferation, metastasis, and tumorigenicity in HCC.
    [Cell Death Discovery]

    Full Article

    A Versatile Microfluidic Tool for the 3D Culture of HepaRG Cells Seeded at Various Stages of Differentiation

    Researchers designed a device that reproduced series of liver microarchitectures, each permitting the 3D culture of hepatocytes by confining them to a chamber that was separated from the medium conveying channel by very thin slits.
    [Scientific Reports]

    Full Article

    C/EBP-α Induces Autophagy by Binding to Beclin1 through Its Own Acetylation Modification in Activated Hepatic Stellate Cells

    Scientists characterized the consequence of CCAAT/enhancer binding protein α overexpression on the expression of proteins LC3B, P62, ATG5 and Beclin1 which were related to autophagy in hepatic stellate cells.
    [Experimental Cell Research]

    Full Article

    Scientific resources to support your organoids research. Learn More!
    REVIEWS

    Roles of Nuclear Receptors in Hepatic Stellate Cells

    Scientists summarize the recent progress in the understanding of the regulatory role of nuclear receptors in hepatic stellate cells and their potential as drug targets in liver fibrosis.
    [Expert Review of Gastroenterology & Hepatology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Can-Fite Gears Up to Initiate Pivotal Phase III Liver Cancer Study

    Can-Fite BioPharma Ltd. announced it has completed preparatory work ahead of the anticipated initiation of patient enrollment for its pivotal Phase III registration trial of Namodenoson in the treatment of hepatocellular carcinoma, the most common form of liver cancer.
    [Can-Fite Biopharma Ltd.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Fatty Liver Disease

    Johns Hopkins University School of Medicine – Saint Petersburg, Florida, United States

    Postdoctoral Associate – Liver Cancer

    University of Minnesota – Austin, Minnesota, United States

    PhD Scholar – Hepatocellular Plasticity

    University of Southern Denmark – Odense, Denmark

    Postdoctoral Scientist – Hepatic Metabolism

    Massachusetts General Hospital – Boston, Massachusetts, United States

    Postdoctoral Fellow – Liver Metabolism

    German Research Center for Environmental Health – Neuherberg, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Hepatic Cell News Twitter