Hepatic Cell News Volume 5.26 | Jul 16 2021

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    2021-07-16 | HCN 5.26


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.26 – 16 July, 2021
    TOP STORY

    FXR Activation Protects against NAFLD via Bile-Acid-Dependent Reductions in Lipid Absorption

    Using comprehensive lipidomic analyses, the authors showed that FXR activation in mice or humans specifically reduced hepatic levels of mono- and polyunsaturated fatty acids.
    [Cell Metabolism]

    Abstract

    Free Wallchart: Dynamic Modeling in Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Nucleus RNA-Seq2 Reveals Functional Crosstalk between Liver Zonation and Ploidy

    Scientists developed a single-nucleus RNA-seq2 method tailored for the comprehensive analysis of the nuclear transcriptome from frozen tissues, allowing the dissection of all cell types present in the liver, regardless of cell size or cellular fragility.
    [Nature Communications]

    Full Article

    Immunotherapy-Based Targeting of MSLN+ Activated Portal Fibroblasts Is a Strategy for Treatment of Cholestatic Liver Fibrosis

    Researchers showed that anti-Mesothelin (Msln) immunotoxins killed the Msln-expressing fibroblasts and reduced collagen type I deposition in fibrotic liver, indicating that agents that specifically killed Msln-expressing cells should be a useful treatment for cholestatic fibrosis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Hepatitis B Virus Evades Immune Recognition via RNA Adenosine Deaminase ADAR1-Mediated Viral RNA Editing in Hepatocytes

    Scientists identified adenosine deaminases acting on RNA 1 (ADAR1), which was a key factor in hepatitis B virus evasion from interferon responses in hepatocytes.
    [Cellular & Molecular Immunology]

    Abstract

    Sorafenib Fails to Trigger Ferroptosis across a Wide Range of Cancer Cell Lines

    Using a combination of well-defined genetically engineered tumor cell lines and canonical small molecule ferroptosis inhibitors, researchers provided unequivocal evidence that sorafenib did not induce ferroptosis in a series of tumor cell lines unlike the cognate system xc− inhibitors sulfasalazine and erastin.
    [Cell Death & Disease]

    Full Article

    Depdc5 Deficiency Exacerbates Alcohol-Induced Hepatic Steatosis via Suppression of PPARα Pathway

    The authors found that aberrant activation of mTORC1 was likely attributed to the reduction of DEP domain-containing protein 5 in the livers of ethanol-fed mice or alcohol-related liver disease patients.
    [Cell Death & Disease]

    Full Article

    USP29-Mediated HIF1α Stabilization Is Associated with Sorafenib Resistance of Hepatocellular Carcinoma Cells by Upregulating Glycolysis

    Investigators reported the ubiquitin-specific peptidase USP29 as a new regulator of HIF1α and of aerobic glycolysis during the development of Sorafenib resistance in hepatocellular carcinoma.
    [Oncogenesis]

    Full Article

    Parthenolide, Bioactive Compound of Chrysanthemum parthenium L., Ameliorates Fibrogenesis and Inflammation in Hepatic Fibrosis via Regulating the Crosstalk of TLR4 and STAT3 Signaling Pathway

    Scientists focused on the regulatory effects of parthenolide, a bioactive component derived from Chrysanthemum parthenium L., against hepatic fibrosis via regulating the crosstalk of toll-like receptor 4 and signal transducer and activator of transcription 3 in activated hepatic stellate cells.
    [Phytotherapy Research]

    Abstract

    Collagen and Elastic Fibres in Acute and Chronic Liver Injury

    Researchers investigated whether immunohistochemistry and multiplexing for collagen type (I & III) and elastic fibers and a modified Victoria blue method could be helpful.
    [Scientific Reports]

    Full Article

    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    REVIEWS

    Dietary Carbohydrates and Fats in Nonalcoholic Fatty Liver Disease

    Scientists review cross-sectional studies on dietary habits of patients with nonalcoholic fatty liver disease and randomized controlled trials on the effects of altering dietary macronutrients on intrahepatic triglyceride.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    Roles of Nuclear Receptors in Hepatic Stellate Cells

    The authors summarize the recent progress in the understanding of the regulatory role of nuclear receptors in hepatic stellate cells and their potential as drug targets in liver fibrosis.
    [Expert Review of Gastroenterology & Hepatology]

    Full Article

    INDUSTRY AND POLICY NEWS

    New Clinical Study Investigates Using Integrated Diagnostics to Enable Precision Medicine for Liver Cancer Patients

    Perspectum announced that a new prospective, observational, cohort study called Precision medicine for liver tumours with quantitative magnetic resonance imaging and whole genome sequencing is underway.
    [Perspectum, Inc.]

    Press Release

    TransMedics Announces Positive FDA Advisory Committee Vote for the OCS Liver System

    TransMedics Group, Inc. announced that after review and discussion of TransMedics’ clinical evidence from the OCS Liver PROTECT trial, the Gastroenterology and Urology Devices Panel of the Medical Devices Advisory Committee convened by the US FDA has issued a favorable vote in support of approval of the OCS Liver System.
    [TransMedics Group, Inc. (BioSpace, Inc.)]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Cancer Immunometabolism

    November 29 – December 1, 2021
    Barcelona, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cell Biology of Liver Metabolism

    Helmholtz Zentrum München – Munich, Germany

    Postdoctoral Fellowship – Fatty Liver Disease

    Johns Hopkins University School of Medicine – Saint Petersburg, Florida, United States

    Postdoctoral Associate – Liver Cancer

    University of Minnesota – Austin, Minnesota, United States

    PhD Scholar – Hepatocellular Plasticity

    University of Southern Denmark – Odense, Denmark

    Postdoctoral Fellow – Liver Metabolism

    German Research Center for Environmental Health – Neuherberg, Germany

    > See All Jobs

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