Hepatic Cell News Volume 5.27 | Jul 23 2021

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    2021-07-23 | HCN 5.27


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.27 – 23 July, 2021
    TOP STORY

    EGFR Activation Limits the Response of Liver Cancer to Lenvatinib

    The combination of the epidermal growth factor receptor (EGFR) inhibitor gefitinib and lenvatinib displayed potent anti-proliferative effects in vitro in liver cancer cell lines that expressed EGFR.
    [Nature]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    CD8+ Tissue-Resident Memory T Cells Promote Liver Fibrosis Resolution by Inducing Apoptosis of Hepatic Stellate Cells

    Single-cell transcriptome analysis and FACS analysis revealed CD69+CD103−CD8+ Trm cell enrichment in non-alcoholic steatohepatitis resolution livers.
    [Nature Communications]

    Full Article

    Kupffer Cell Restoration after Partial Hepatectomy Is Mainly Driven by Local Cell Proliferation in IL-6-Dependent Autocrine and Paracrine Manners

    Researchers addressed the question of whether liver macrophage restoration resulted from circulating monocyte infiltration or local kupffer cell proliferation in regenerating livers after partial hepatectomy and uncovered the underlying mechanisms.
    [Cellular & Molecular Immunology]

    Full Article

    NEU4 Inhibits Motility of HCC Cells by Cleaving Sialic Acids on CD44

    Scientists found the NEU4 expression was significantly down-regulated in hepatocellular carcinoma (HCC) tissues, which was correlated with high grades and poor outcomes of HCC.
    [Oncogene]

    Abstract

    PPM1G Promotes the Progression of Hepatocellular Carcinoma via Phosphorylation Regulation of Alternative Splicing Protein SRSF3

    Investigators showed that the PPM1G, a protein phosphatase, regulated the phosphorylation of SRSF3 in hepatocellular carcinoma (HCC) and contributed to the proliferation, invasion, and metastasis of HCC.
    [Cell Death & Disease]

    Full Article

    SLC38A4 Functions as a Tumor Suppressor in Hepatocellular Carcinoma through Modulating Wnt/β-Catenin/MYC/HMGCS2 Axis

    Researchers identified a common molecular event which would provide a novel prognostic biomarker and therapeutic target for hepatocellular carcinoma.
    [British Journal of Cancer]

    Abstract

    The Aetiology and Molecular Landscape of Insulin Resistance

    Specific deletion of Acot12, the major acyl-CoA thioesterase, induced the accumulation of acetyl-CoA and resulted in the stimulation of de novo lipogenesis and cholesterol biosynthesis in the liver.
    [Experimental and Molecular Medicine]

    Full Article

    Bromodomain-Containing Protein BRPF1 Is a Therapeutic Target for Liver Cancer

    Gene ablation or pharmacological inactivation of bromodomain and PHD finger containing 1 (BRPF1) significantly attenuated hepatocellular carcinoma cell growth in vitro and in vivo.
    [Communications Biology]

    Full Article

    Dynamin-Related Protein 1 Deficiency Accelerates Lipopolysaccharide-Induced Acute Liver Injury and Inflammation in Mice

    Researchers hypothesized that dynamin-related protein 1 defects were a causal factor directly involved in liver disease development and stimulated liver disease progression.
    [Communications Biology]

    Full Article

    Circulating miRNA Is a Useful Diagnostic Biomarker for Nonalcoholic Steatohepatitis in Nonalcoholic Fatty Liver Disease

    After selecting miRNAs for the diagnosis of nonalcoholic steatohepatitis, scientists analyzed the diagnostic accuracy of each miRNA and the combination of miRNAs.
    [Scientific Reports]

    Full Article

    Elevated S-Adenosylhomocysteine Induces Adipocyte Dysfunction to Promote Alcohol-Associated Liver Steatosis

    Researchers used 3-deazaadenosine, which selectively elevated intracellular S-adenosylhomocysteine levels by blocking its hydrolysis. Fully differentiated 3T3-L1 adipocytes were treated in vitro for 48 hours with DZA and analyzed for lipolysis, adipokine release and differentiation status.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Pathophysiological Communication between Hepatocytes and Non-Parenchymal Cells in Liver Injury from NAFLD to Liver Fibrosis

    Scientists overview recent findings from human study and animal models on the pathophysiological communication among hepatocytes, Kupffer cells, hepatic stellate cells and liver sinusoidal endothelial cells during the disease development.
    [Advanced Drug Delivery Reviews]

    Full Article

    Distinctive Features of Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease

    At variance with viral hepatocellular carcinoma (HCC), nonalcoholic fatty liver disease-HCC shows a frequent association with cardiovascular co-morbidities, absence of cirrhosis in up to half of patients and an association with persistently normal transaminase values.
    [Digestive and Liver Disease]

    Abstract

    INDUSTRY AND POLICY NEWS

    Eureka Therapeutics Announces Initiation of Phase I/II ARYA-3 Clinical Trial of GPC3 Targeting ARTEMIS® T Cell Therapy in Liver Cancer

    Eureka Therapeutics, Inc. announced the initiation of a Phase I/II clinical trial of ECT204, a GPC3 targeting ARTEMIS® T-cell therapy for the treatment of hepatocellular carcinoma.
    [Eureka Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Autophagy in Brain Health and Disease

    May 11 – 14, 2022
    Sant Feliu de Guixols, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Fatty Liver Disease

    Beckman Research Institute of City of Hope – Duarte, California, United States

    Postdoctoral Fellow – Cell Biology of Liver Metabolism

    Helmholtz Zentrum München – Munich, Germany

    Postdoctoral Fellowship – Fatty Liver Disease

    Johns Hopkins University School of Medicine – Saint Petersburg, Florida, United States

    Postdoctoral Associate – Liver Cancer

    University of Minnesota – Austin, Minnesota, United States

    Postdoctoral Fellow – Liver Metabolism

    German Research Center for Environmental Health – Neuherberg, Germany

    > See All Jobs

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