 | | Vol. 5.28 – 30 July, 2021 |
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| Researchers explored the mechanistic role of super-enhancers linking cytokine TNFα with chemokine amplification in alcoholic hepatitis.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A HepG2 cell line, which inducibly expressed ferroportin-GFP, was established to test the ability of siRNAs directed against components of the ubiquitin system to prevent BMP6- and exogenous hepcidin-induced ferroportin degradation.
[Haematologica] |
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| Researchers reported that SET and MYND domain-containing protein 3 (SMYD3) expression in hepatocellular carcinoma (HCC) was an independent prognostic factor for survival and promoted the proliferation and migration of HCC cells.
[Cell Death & Disease] |
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| In the presence of NOXA, BIM-deficient hepatocellular carcinoma cells could be in turn strongly sensitized for cell death induction by the combination of sorafenib with TNF-related apoptosis-inducing ligand .
[Cell Death & Disease] |
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| Through overexpressing TMEM220 in hepatocellular carcinoma cell lines, scientists found that the proliferation of cancer cells was significantly slowed down and metastasis was significantly reduced.
[Cancer Gene Therapy] |
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| Investigators identified the role of tribbles homolog 2 (TRIB2) to relieve oxidative damage via reducing the availability of ubiquitin that was essential for the ubiquitination and subsequent degradation of glutathione peroxidase 4.
[Cell Death Discovery] |
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| Scientists evaluated the expression of a recently identified circular RNA, hsa_circ_0005986; determined its clinical significance; and evaluated its potential as a biomarker of hepatocellular carcinoma.
[Scientific Reports] |
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| In a subset of 94 patients with hepatocellular carcinoma (HCC), a linear mixed effects model adjusted for confounders showed that serum magnesium at diagnosis of HCC was lower than before diagnosis of the tumor.
[Scientific Reports] |
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| Scientists explored the efficacy of two protocols to decellularize porcine liver tissue using varying combinations of commonly used chemical agents such as Triton X-100, Sodium Dodecyl Sulphate and ammonium hydroxide.
[Scientific Reports] |
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| Investigators discuss how the hepatic microenvironment adapts to pathologies characterized by chronic inflammation and metabolic alterations. They illustrate how these immunological or metabolic changes alter immunosurveillance and thus hinder or promote the development of primary liver cancer.
[Nature Reviews Cancer] |
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| The authors highlight how lipids, carbohydrates, and proteins dynamically change and orchestrate liver regeneration. They discuss translational studies in which metabolic intervention has been used to treat chronic liver diseases.
[Trends in Endocrinology and Metabolism] |
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| Arrowhead Pharmaceuticals, Inc. announced that it was granted Breakthrough Therapy designation by the US FDA for ARO-AAT, also known as TAK-999, the company’s second-generation investigational RNA interference therapeutic being co-developed with Takeda Pharmaceutical Company Ltd. as a treatment for the rare genetic liver disease associated with alpha-1 antitrypsin deficiency.
[Arrowhead Pharmaceuticals, Inc.] |
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| May 25 – 27, 2022
Hinxton, England, United Kingdom |
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| University of Oslo – Oslo, Norway |
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| Beckman Research Institute of City of Hope – Duarte, California, United States |
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| Helmholtz Zentrum München – Munich, Germany |
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| Johns Hopkins University School of Medicine – Saint Petersburg, Florida, United States |
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| University of Minnesota – Austin, Minnesota, United States |
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