 | | Vol. 5.29 – 6 August, 2021 |
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| In the liver, ductal cells rarely proliferate during homeostasis but do so transiently after tissue injury. Using organoid co-cultures that recapitulated the ductal-to-mesenchymal cell architecture of the portal tract, researchers demonstrated that a subpopulation of mouse periportal mesenchymal cells exerted dual control on proliferation of the epithelium.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Single-cell transcriptomics revealed three transcriptionally heterogeneous hematopoietic stem cell and multipotent progenitor subsets, among which a CD93-enriched subset exhibited enhanced stem cell properties.
[Cell Research] |
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| Mass spectrometry analysis of the β-hydroxybutyrylome in mouse liver revealed 891 sites of Kbhb within 267 proteins enriched for fatty acid, amino acid, detoxification, and one-carbon metabolic pathways.
[Cell Reports] |
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| Investigators compared methionine adenosyltransferase 1A (MAT1A) interactome in normal versus cancerous livers by mass spectrometry to reveal interactions with 14-3-3ζ. The MATα1/14-3-3ζ complex was critical for the expression of 14-3-3ζ.
[Oncogene] |
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| Researchers evaluated the therapeutic potential of givinostat, a histone deacetylase inhibitor, in the treatment of nonalcoholic steatohepatitis in vivo and in vitro.
[Acta Pharmacologica Sinica] |
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| Scientists reported a compound, trilobolide-6-O-isobutyrate, isolated from the flowers of Wedelia trilobata with a markedly cytotoxic effect on hepatocellular carcinoma cells.
[Phytotherapy Research] |
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| Investigators analyzed the undesirable effects of mild, moderate and high doses of rosuvastatin in CD-1 male mice who received a cholesterol-rich diet, focusing on the morphological and functional changes on hepatocyte mitochondria.
[Scientific Reports] |
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| Scientists reported a distant cardioprotective mechanism involving hepatic cell mobilization to the ischemic myocardium in response to experimental myocardial ischemia–reperfusion injury.
[Scientific Reports] |
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| The authors investigated the association between the histopathological severity of nonalcoholic fatty liver disease (NAFLD) and carotid intima-media thickness in Japanese patients with liver biopsy-proven NAFLD.
[Scientific Reports] |
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| Investigators explored Xanthomicrol’s effects on migration and invasion ability of the human human hepatocellular carcinoma Huh7 cell line.
[Journal of Pharmacy and Pharmacology] |
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| Scientists summarize the current knowledge of how different crosstalk between liver sinusoidal endothelial cells and other liver cells, including hepatocytes, hepatic stellate cells, macrophoges, immune cells in liver and extra cellular matrix contribute to the physiological function and the progrssion from liver fibrosis to cirrhosis, or even to hepatocellular carcinoma.
[Digestive and Liver Disease] |
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| 89bio, Inc announced that it has completed target enrollment of 20 patients in the paired-biopsy, open-label histology cohort in biopsy-confirmed fibrosis stage F2 – F3 NASH patients.
[89bio, Inc.] |
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| October 27 – 29, 2021
Virtual |
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| University Hospital of Würzburg – Würzburg, Germany |
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| University of Oslo – Oslo, Norway |
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| Beckman Research Institute of City of Hope – Duarte, California, United States |
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| Helmholtz Zentrum München – Munich, Germany |
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| Johns Hopkins University School of Medicine – Saint Petersburg, Florida, United States |
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