 | | Vol. 5.33 – 3 September, 2021 |
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| Researchers used a mouse model of hepatitis B virus (HBV) infection, in which HBV-specific naive CD8+ T cells recognizing hepatocellular antigens were driven into a state of immune dysfunction, to identify a subset of Kupffer cells that cross-presented hepatocellular antigens upon interleukin-2 administration.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the functional contribution of Yes-associated protein and/or transcriptional co-activator with PDZ-binding motif (TAZ) during c-MYC induced liver tumor development.
[Journal of Hepatology] |
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| Researchers investigated restoration of hepatocyte functions by HNF4A mRNA transfection in vitro, and analyzed the attenuation of liver fibrosis and cirrhosis in multiple mouse models, by delivering hepatocyte-targeted biodegradable lipid nanoparticles encapsulating HNF4A mRNA.
[Journal of Hepatology] |
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| The authors showed that pirfenidone, an anti-lung fibrosis drug, inhibited hepatic stellate cell activation and liver fibrosis in a Glutaredoxin-1 (GLRX)-dependent manner. Glrx depletion exacerbated liver fibrosis, and decreased GLRX and increased protein S-glutathionylation were observed in fibrotic mouse and human livers.
[Science Advances] |
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| Investigators ascertained the integration frequency of recombinant adeno-associated viral (AAV) vectors in human hepatocytes transduced either ex vivo or in vivo and subsequently expanded in a mouse model of xenogeneic liver regeneration.
[Molecular Therapy] |
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| Single-cell RNA sequencing was performed to decipher transcriptomic profiles of single cells from hepatocellular carcinoma (HCC) samples. Cell-type-specific transcripts were identified and used for deducing the cell-type-specific gene signature scores of plasma RNA from patients with and without HCC.
[Clinical Chemistry] |
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| Using a Thpo translational reporter, scientists found that the liver but not the bone marrow was the major source of thrombopoietin protein after myeloablation. Mice with conditional Thpo deletion from hepatocytes showed significant defects in hematopoietic stem cell regeneration and hematopoietic rebound after myeloablation.
[eLife] |
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| Investigators demonstrated that treatment of liver fibrosis with both human induced pluripotent stem cell-derived macrophage populations and especially M2 subtype significantly reduced fibrogenic gene expression and disease associated histological markers in immunodeficient Rag2−/−γc−/− mice model, making this approach a promising cell-based avenue to ameliorate fibrosis.
[Stem Cells] |
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| Researchers investigated the effects of pantoprazole (PPZ), a proton pump inhibitor, against liver fibrosis in a bile duct ligation rat model, human hepatic stellate cell (HSC) line LX-2 and mouse primary HSCs, and explored the potential mechanisms underlying the effects of PPZ in vitro and in vivo.
[Acta Pharmacologica Sinica] |
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| Protein phosphatase magnesium-dependent 1 delta (PPM1D) mRNA expression was significantly higher in several human cancers, including hepatocellular carcinoma (HCC), than in the corresponding normal human tissues. The PPM1D mRNA high expression in HCC was significantly correlated with poor prognosis.
[Aging] |
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| The authors explored the role of exosomal miR-15a derived from mesenchymal stem cells (MSCs) and its related mechanisms in hepatocellular carcinoma (HCC).The exosomes from MSCs restrained HCC cell proliferative, migrating, and invasive potentials, and accelerated their apoptosis.
[Cell Death Discovery] |
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| Scientists analyzed the effect of obesity on advanced glycation endproducts (AGEs) accumulation, AGE-receptors and AGE-detoxification, and whether the absence of RAGE may have improved hepatosteatosis and inflammation, by comparing the liver of lean control, obese and obese RAGE-deficient mice.
[Scientific Reports] |
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| The authors systematically evaluate the characteristics, biogenesis, mechanisms and functions of circular RNAs (circRNAs) in hepatocellular carcinoma and further discuss the current shortcomings and potential directions of prospective studies on liver cancer-related circRNAs.
[Journal of Hematology & Oncology] |
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| Investigators discuss state-of-the-art lung, liver, and kidney 3D organoid systems utilizing the adverse outcomes approach to study SARS-CoV-2 molecular pathogenesis.
[Journal of Molecular Biology] |
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| Scientists review the effect of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway on alleviating cholestasis, and summarize recent evidence about natural Nrf2 activators with hepatoprotective effect in various models of cholestatic liver injury, thus providing theoretical reference for the development of anti-cholestatic drug.
[European Journal of Pharmacology] |
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| The National Institutes of Health is awarding seven projects a total of $18.15 million over five years to a new effort focused on interoception — the ways in which organisms sense and regulate signals within their bodies. One project will investigate the functional identification of vagal sensory neurons innervating the liver.
[National Institutes of Health] |
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| October 19, 2021
London, England, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | European Centre Study Diabetes – Strasbourg, France |
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| | Sidney Kimmel Cancer Center at Jefferson Health – Philadelphia, Pennsylvania, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| University of Luxembourg – Luxembourg City, Luxembourg |
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