 | | Vol. 5.34 – 10 September, 2021 |
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| Degradation of Smc5/6 complex and accumulation of DNA damage were observed in both in vivo and in vitro hepatitis B virus (HBV) infection models. Rescue experiments were performed using nitazoxanide, which inhibited degradation of the Smc5/6 complex by HBV regulatory protein X (HBx).
[Journal of Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Deletion of cannabinoid receptor-1 receptors in hepatocytes did not alter the development of nonalcoholic fatty liver disease (NAFLD) in mice fed a high sucrose high fat diet or high fat diet.
[Journal of Clinical Investigation] |
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| Researchers perturbed the hepatic transcriptome through nutrient regulators to identify enduring properties of pathway organization. Diurnal regulation of energy metabolism alleviated inflammatory and proliferative stresses under physiological and pathological conditions.
[Cell Reports] |
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| The authors evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the cancer stem cell-like properties of hepatocellular carcinoma (HCC) tumor-repopulating cells, and assessed its preclinical efficacy in models of HCC patient-derived xenografts
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists showed that miR-30c-5p was down-regulated in hepatocellular carcinoma (HCC) and significantly associated with survival and presence of tumor size in patients with HCC, and demonstrated that aberrant miR-30c-5p markedly affected HCC cell proliferation and migration.
[Molecular Therapy-Nucleic Acids] |
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| Investigators determined that lipin 1 deficiency induced widespread alternative mRNA splicing in liver during fasting, much of which was normalized by refeeding. The role of lipin 1 in mRNA splicing was largely independent of its enzymatic function.
[JCI Insight] |
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| Researchers reported that IFN-α2b enhanced the histone deacetylase 3 (HDAC3)-mediated de-2-hydroxyisobutyrylation of histone H4 lysine 8 (H4K8) on hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) minichromosome to restrict the cccDNA transcription in liver.
[Acta Pharmacologica Sinica] |
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| Investigators examined dietary cholesterol-induced reorganization of whole body sterol and bile acid homeostasis in adult mice with inducible hepatocyte-specific Smo deletion. They demonstrated Smo in hepatocytes played a regulatory role in sensing and feedback regulation of cholesterol balance driven by excess dietary cholesterol.
[iScience] |
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| Scientists showed single cell ribonucleic acid sequencing analysis of human tumor, background liver, and patient derived xenograft to demonstrate gene expression patterns within tumor and to identify intratumor cell subtype heterogeneity to define differing roles in pathogenesis based on intracellular signaling in pediatric hepatoblastoma.
[Communications Biology] |
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| The authors determined toll-like receptor (TLR) expression patterns in peripheral blood mononuclear cells of non-alcoholic fatty liver disease (NAFLD) patients and controls, their relation to intestinal microbiota and the impact of TLRs found altered in NAFLD development.
[Scientific Reports] |
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| Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Researchers examined the in vitro interactions of some key repurposed drugs advocated to treat COVID-19 with the key drug transporters of hepatocytes.
[Scientific Reports] |
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| The role of miR-30c in HCC was comprehensively investigated by using bioinformatics and experiments in vitro. The multiple databases were combined to predict and screen the target genes and upstream long non-coding RNAs of miR-30c, and then constructed a competitive endogenous RNA regulatory network with miR-30c as the central miRNA.
[Bioengineered] |
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| FA2H was a direct target of miR-3075 and small interfering RNA depletion of FA2H in adipocytes, myocytes and primary hepatocytes led to increased insulin sensitivity. In chronic obesity, hepatocyte exosomes promoted a state of insulin resistance.
[Nature Metabolism] |
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| Genetic studies have provided new insights into the pathogenesis of cholangiocarcinoma (CCA), and two aberrations that drive the pathogenesis of non-fluke-associated intrahepatic CCA, fibroblast growth factor receptor 2 fusions and isocitrate dehydrogenase gain-of-function mutations, can be therapeutically targeted.
[Nature Reviews Disease Primers] |
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| The authors comprehensively describe developments in the liver cancer stem cell (CSC) field with emphasis on experiments utilizing single-cell transcriptomics to understand liver CSC heterogeneity, lineage-tracing and cell-ablation studies of liver CSCs, and the influence of the CSC niche and tumour microenvironment on liver cancer stemness, including interactions between CSCs and the immune system.
[Nature Reviews Gastroenterology & Hepatology] |
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| Inversago Pharma, Inc. announced that following the receipt of a No Objection Letter from Health Canada on July 29, 2021, it has dosed the first volunteers with INV-202 in its first-in-human Phase I clinical trial, which will evaluate the safety, tolerability, and pharmacokinetics of this compound.
[Inversago Pharma, Inc.] |
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| Terns Pharmaceuticals, Inc. announced the completion of patient enrollment of Part 1 of the AVIATION Trial, a Phase Ib clinical trial evaluating TERN-201, an orally-administered, highly selective inhibitor of vascular adhesion protein-1 (VAP-1), in patients with non-alcoholic steatohepatitis (NASH).
[Terns Pharmaceuticals, Inc. (GlobeNewswire, Inc.)] |
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| Inventiva, a clinical-stage biopharmaceutical company focused on the development of oral small molecule therapies for the treatment of non-alcoholic steatohepatitis (NASH), mucopolysaccharidoses and other diseases, announced the initiation of its NATiV3 Phase III clinical trial evaluating lanifibranor for the treatment of NASH.
[Inventiva] |
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| October 19 – 20, 2021
Virtual |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| | European Centre Study Diabetes – Strasbourg, France |
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| | Sidney Kimmel Cancer Center at Jefferson Health – Philadelphia, Pennsylvania, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| University of Luxembourg – Luxembourg City, Luxembourg |
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