 | | Vol. 5.35 – 17 September, 2021 |
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| In mouse models of liver injury, ductular reaction cells express genes involved in angiogenesis. In vitro, human liver-derived organoids produced SLIT2 and induced tube formation of endothelial cells.
[Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| On a non-alcoholic fatty liver disease-inducing diet, hepatocyte-specific HuR-deficiency resulted in exacerbated inflammation, fibrosis and hepatocellular carcinoma -like tumor development. A multi-omic approach revealed that HuR orchestrated a protective network of hepatic-metabolic and lipid homeostasis-maintaining pathways.
[Hepatology] |
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| Researchers developed a simple and robust human liver cell-based system modeling a clinical prognostic liver signature predicting long-term liver disease progression toward hepatocellular carcinoma.
[Nature Communications] |
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| Investigators showed that the hepatitis C virus was restricted by an iron-dependent mechanism resembling the one triggering ferroptosis and mediated by the non-canonical desaturation of oleate to Mead acid and other highly unsaturated fatty acids by fatty acid desaturase 2 (FADS2).
[Cell Chemical Biology] |
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| Programmed cell death 10 (PDCD10) was significantly upregulated in hepatocellular carcinoma (HCC), which also correlated with aggressive clinicopathological characteristics and predicts poor prognosis of HCC patients after liver resection. High PDCD10 expression promoted HCC cell proliferation, migration, and invasion in vitro and tumor growth, metastasis in vivo.
[Cell Death & Disease] |
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| Scientists utilized a polarized hepatocyte culture model and a human liver chimeric mouse model to dissect the roles of open reading frame 3 (ORF3) in genotype 3 Hepatitis E virus (HEV) release and persistent infection. They showed that ORF3’s absence substantially decreased HEV replication and virion release from the apical surface but not the basolateral surface of polarized hepatocytes.
[Journal of Virology] |
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| Researchers investigated the roles of Lipocalin 2 (LCN2) in chronic inflammation and fibrosis, using repeated carbon tetrachloride in mineral-oil injection. Hepatic and serum LCN2 levels were remarkably higher in the mineral oil-injected wild type group compared to the CCl4.
[Laboratory Investigation] |
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| The authors found that, upon knockdown of DNA Polymerase Theta (POLQ), the proliferation and migration of hepatocellular carcinoma cells decreased and apoptosis percentage increased.
[Cancer Cell International] |
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| Scientists investigated how liver fibrosis and features of non-alcoholic steatohepatitis (NASH) could be modeled using an in vitro microphysiological system (MPS). The NASH MPS model comprised a co-culture of primary human liver cells, which were cultured in a variety of conditions including +/− excess sugar, fat, exogenous TGFβ, or LPS.
[Communications Biology] |
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| The authors reported a strategy for chronic liver disease treatment by induction of integrin αvβ3 mediated cell apoptosis using a rationally designed protein (ProAgio). ProAgio was designed to target integrin αvβ3 at a novel site, which was highly expressed in activated hepatic stellate cells, angiogenic endothelium, and capillarized liver sinusoidal endothelial cells.
[Communications Biology] |
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| Investigators showed dual regulatory functions of bone marrow-derived mesenchymal stem cells in attenuating hepatic fibrosis by promoting Ly6Chi/Ly6Clo subset conversion and Ly6Clo macrophage restoration through secreting antifibrogenic-cytokines and activating the apoptotic pathway.
[Cell Death Discovery] |
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| Scientists demonstrated that the expression of lncRNA NEAT1 was increased and the expression of miR-139-5p was decreased in fibrotic liver tissues. LncRNA NEAT1 could sponge miR-139-5p and promoted hepatic stellate cells activation by directly inhibiting the expression of miR-139-5p.
[Cell Death Discovery] |
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| The utility of the fluorescence imaging of hepatocellular carcinoma (HCC) using a β-galactosidase (β-Gal)-activatable fluorescence probe SPiDER-βGal was examined. Live cell imaging of HCC cell lines and imaging of tumour-bearing model mice were performed using SPiDER-βGal.
[Scientific Reports] |
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| The authors provide an overview of the contribution of metabolomics and lipidomics in clinical studies to identify biomarkers associated with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis.
[Nature Reviews Gastroenterology & Hepatology] |
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| Investigators systematically profile the overall mechanism of radiation-induced liver injury and the effects of radiation on hepatocyte senescence, laying foundations for the development of new therapies.
[Cell Death Discovery] |
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| CohBar, Inc. announced the United States Patent and Trademark Office has granted a patent, US No. 11,111,271, covering CohBar’s lead candidate CB4211 and related compositions, as well as methods of treatment, including methods of treating NASH.
[CohBar, Inc.] |
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| Camurus announced that the US FDA has granted orphan drug designation for the company’s investigational medicinal product, octreotide subcutaneous depot (CAM2029), for the treatment of autosomal dominant polycystic liver disease.
[Camurus (PR Newswire, Inc.)] |
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| | Queen’s University Belfast – Belfast, Ireland |
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| | Herman B Wells Center for Pediatric Research – Indianapolis, Indiana, United States |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | European Centre Study Diabetes – Strasbourg, France |
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