Hepatic Cell News Volume 5.40 | Oct 29 2021

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    2021-10-29 | HCN 5.40


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.40 – 29 October, 2021
    TOP STORY

    Role of the IgG4-Related Cholangitis Autoantigen Annexin A11 in Cholangiocyte Protection

    Scientists investigated the expression and function of annexin A11 in human cholangiocytes and a potential role of IgG1/IgG4-mediated autoreactivity against annexin A11 in the pathogenesis of IgG4-related cholangitis.
    [Journal of Hepatology]

    Full ArticleGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Adenosine Deaminase 2 Produced by Infiltrative Monocytes Promotes Liver Fibrosis in Nonalcoholic Fatty Liver Disease

    The authors suggested that infiltrative monocytes promoted fibrogenesis in nonalcoholic fatty liver disease via adenosine deaminase 2-mediated autocrine/paracrine signaling culminating in enhanced PDGF-B production.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Rapamycin Targets STAT3 and Impacts C-Myc to Suppress Tumor Growth

    Researchers used a chemical proteomics strategy that had identified STAT3, a transcription factor considered to be undruggable, as a direct functional protein target of rapamycin. They showed that rapamycin treatment in cell culture significantly inhibited c-Myc-regulated gene expression.
    [Cell Chemical Biology]

    AbstractGraphical Abstract

    Circular RNA circUBE2J2 Acts as the Sponge of microRNA-370-5P to Suppress Hepatocellular Carcinoma Progression

    Scientists suggested that circUBE2J2 may have acted as a competing endogenous RNA to regulate KLF7 expression through sponging miR-370-5P, and played regulatory functions in hepatocellular carcinoma.
    [Cell Death & Disease]

    Full Article

    ARID1A Deficiency Weakens BRG1-RAD21 Interaction That Jeopardizes Chromatin Compactness and Drives Liver Cancer Cell Metastasis

    To address the effect of Arid1a deficiency on chromatin organization, investigators generated chromatin interaction matrices, and exploited the conformation changes upon Arid1a depletion in hepatocytes.
    [Cell Death & Disease]

    Full Article

    Impact of Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocellular Carcinoma: Cancer Metabolism and Immune Status

    Researchers examined phosphorylated nuclear factor erythroid 2–related factor 2 (P-NRF2) expression in surgically resected primary hepatocellular carcinoma and investigated the association of P-NRF2 expression with clinicopathological features and patient outcome.
    [Hepatology Communications]

    Full Article

    Single-Cell RNA Transcriptome Landscape of Hepatocytes and Non-Parenchymal Cells in Healthy and NAFLD Mouse Liver

    To obtain a cellular resolution of pathogenesis, 82,168 single-cell transcriptomes across different nonalcoholic fatty liver disease stages were profiled, identifying hepatocytes and 12 other non-parenchymal cell types.
    [iScience]

    Full ArticleGraphical Abstract

    HES5-Mediated Repression of LIGHT Transcription May Contribute to Apoptosis in Hepatocytes

    The authors reported that the lymphokine LIGHT/TNFSF14 was upregulated in the murine NAFLD livers and in hepatocytes treated with free fatty acids
    [Cell Death Discovery]

    Full Article

    RBM15 Promotes Hepatocellular Carcinoma Progression by Regulating N6-Methyladenosine Modification of YES1 mRNA in an IGF2BP1-Dependent Manner

    Researchers determined the clinical value, biological functions, and potential mechanisms of RNA-binding motif protein 15 (RBM15) in hepatocellular carcinoma.
    [Cell Death Discovery]

    Full Article

    The Effects Of Autophagy Inhibition By Chloroquine On Hepatic Stellate Cell Activation In CCl4-induced Acute Liver Injury Mouse Model

    The autophagy attenuation exerted by chloroquine together with the reduction of the expression of the proliferation marker in hepatic stellate cells could lessen the acute liver damage, potentially opening the way to novel therapeutic approaches for hepatic fibrosis.
    [Journal of Gastroenterology and Hepatology]

    Abstract

    Synthesis of Fluorinated imidazole[4,5f][1,10]phenanthroline Derivatives as Potential Inhibitors against the Proliferation of Liver Cancer Cells by Inducing Apoptosis via DNAdamage

    A series of fluorinated imidazole phenanthroline derivatives were synthesized and investigated as potential inhibitors against the growth of liver cancer cells.
    [Chemmedchem]

    Abstract

    Hexafluoropropylene Oxide Dimer Acid (GenX) Exposure Induces Apoptosis in HepG2 Cells

    Scientists investigated the apoptotic capacity of GenX in human liver cells. When representative human-derived liver cells (HepG2 cells) were treated with GenX for 12 hours, cell viability was reduced, and apoptosis was greatly increased.
    [Heliyon]

    Full ArticleGraphical Abstract

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    REVIEWS

    Cirrhosis-Associated Immune Dysfunction

    The intensity of cirrhosis-associated immune dysfunction has important consequences on cirrhosis progression and correlates with the severity of liver insufficiency, bacterial translocation and organ failure.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    Extracellular Vesicles as a New Hope for Diagnosis and Therapeutic Intervention for Hepatocellular Carcinoma

    Reports on the roles of hepatocellular carcinoma (HCC)-derived extracellular vesicles (EVs) in tumorigenesis, and clinical investigations using circulating EVs as a biomarker for HCC and their potential diagnostic are comprehensively summarized and discussed.
    [Cancer Medicine]

    Full Article

    Gut Microbiome and Metabolic Response in Non-Alcoholic Fatty Liver Disease

    Investigators discuss the current state of non-alcoholic fatty liver disease metabolites, gut micro-environmental changes, and the further challenges in digital metabolomics profiling.
    [Clinica Chimica Acta]

    Abstract

    INDUSTRY AND POLICY NEWS

    Ubiquigent Extends and Expands Drug Discovery Collaboration with Bristol Myers Squibb

    Ubiquigent Limited announced the extension and expansion of its long-term collaboration with Bristol Myers Squibb, and will provide Bristol Myers Squibb with increased access to its deubiquitylase enzyme inhibitor drug discovery platform to provide further support to additional therapeutic areas.
    [Ubiquigent Limited (Lifescience Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    2nd AACR-KCA Conference on Precision Medicine in Solid Tumors

    November 10 – 11, 2021
    Seoul, Korea & Online

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    JOB OPPORTUNITIES

    Vice President – Medical Affairs and Dean of the School of Medicine

    Saint Louis University – St. Louis, Missouri, United States

    Postdoctoral Fellow – Molecular Drivers of Non-Alcoholic Fatty Liver Disease

    Genome Institute of Singapore – Singapore, Singapore

    Director – Liver Biology

    Gordian Biotechnology – San Francisco, California, United States

    Postdoctoral Fellow – Cardiovascular Dysfunction and Chronic Liver Disease

    National Institutes of Health – Bethesda, Maryland, United States

    Postdoctoral Associate – Liver Cancer

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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