 | | Vol. 5.41 – 5 November, 2021 |
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| Live cell imaging, histological, biochemical, and molecular studies were used to investigate the mechanisms that underlie the extracellular and intracellular action of recombinant MG53 protein in hepatoprotection.
[Journal of Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors revealed a damage-regulated autophagy modulator (DRAM)-mediated mechanism for exosome secretion and provided the foundation for plasma exosomes as a potential biomarker for nonalcoholic fatty liver disease (NAFLD).
[Science Advances] |
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| Investigators showed that N1-methyladenosine methylation in tRNA was remarkably elevated in hepatocellular carcinoma patient tumor tissues.
[Nature Communications] |
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| Scientists explored the role and mechanism of spectrin beta, non-erythrocytic 1 (SPTBN1) in the autophagy of hepatic stem cells and hepatocellular carcinoma cells.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Researchers confirmed that BEZ235 could suppress the proliferation, invasion and colony conformation abilities of intrahepatic cholangiocarcinoma (ICC) cells in vitro but could not effectively inhibit ICC progression in vivo.
[Cell Death & Disease] |
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| In vitro functional investigations revealed that the interaction between AnnexinA7 and Sorcin regulated epithelial–mesenchymal transition, and then affected migration, invasion, and proliferation in hepatocellular carcinoma cells.
[Cell Death & Disease] |
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| The authors evaluated the potential and feasibility to identify proliferating human hepatocytes from primary human hepatocytes with Raman spectroscopy.
[Stem Cell Research & Therapy] |
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| Researchers performed a targeted delivery of miR-218 expressing DNA plasmid to suppress hepatocellular carcinoma in vitro and in vivo.
[International Journal of Pharmaceutics] |
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| Investigators showed that the expression of high mobility group A1 (HMGA1) was frequently elevated in cholangiocarcinomas and that the high expression of this gene was associated with a poor prognosis.
[Cell Death Discovery] |
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| CircRNA microarray analysis was used to assess the plasma from hepatocellular carcinoma (HCC) patients and healthy controls and to identify circRNAs involved in HCC tumorigenesis.
[Cell Death Discovery] |
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| Scientists investigated the relationship between the expression of EZH1/2 and the level of histone H3 Lysine 27 trimethylation in hepatocellular carcinoma.
[Scientific Reports] |
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| Researchers investigated whether pyruvate dehydrogenase complex (PDC)-E2 interacted with STAT3 in human cholangiocytes and hepatocytes under cholestatic conditions induced by glyco-chenodeoxycholic acid.
[Scientific Reports] |
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| The authors discuss diagnosis, predictors and effects of relapse, behavioural therapies and pharmacotherapies, and they also propose an integrative, multidisciplinary and multimodality approach for treating alcohol use disorder in patients with cirrhosis, especially in the setting of liver transplantation.
[Nature Reviews Gastroenterology & Hepatology] |
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| Scientists discuss the latest clinical data from clinical trials for immune-checkpoint inhibitors for the treatment of hepatocellular carcinoma.
[International Immunopharmacology] |
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| Gannex Pharma Co., Ltd. announced the Investigational New Drug (IND) application approval by US FDA and initiation of global development of ASC43F, a fixed-dose combination with dual targets of thyroid hormone receptor beta and farnesoid X receptor for the treatment of non-alcoholic steatohepatitis (NASH).
[Gannex Pharma Co., Ltd.] |
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| Kintor Pharmaceutical Limited announced that the company has enrolled and dosed its first patient with advanced or refractory solid tumors in a clinical trial of ALK-1 antibody in combination with KN046.
[Kintor Pharmaceutical Limited] |
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| November 22 – 24, 2021
Virtual |
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| | King’s College London – London, England, United Kingdom |
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| | Saint Louis University – St. Louis, Missouri, United States |
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| | Genome Institute of Singapore – Singapore, Singapore |
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| | Gordian Biotechnology – San Francisco, California, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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