 | | Vol. 5.44 – 26 November, 2021 |
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| Scientists identified and characterized a remarkable mutational mechanism in human hepatocellular carcinoma caused by the Hepatitis B virus, by which DNA molecules from the virus were inserted into the tumor genome causing dramatic changes in its configuration.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Agonist-induced stimulator of interferon genes (STING) signaling activation in macrophages was revealed to inhibit covalently closed circular DNA-mediated transcription and hepatitis B virus (HBV) replication via epigenetic modification in hepatocytes.
[Cellular & Molecular Immunology] |
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| The authors revealed that deoxythymidylate kinase (DTYMK) levels significantly increased and correlated with poor prognosis in hepatocellular carcinoma (HCC).
[Cell Reports] |
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| Investigators identified a lncRNA, HOMER3-AS1, which was over-expressed in hepatocellular carcinoma (HCC) and correlated with poor survival of HCC patients. HOMER3-AS1 promoted HCC cellular proliferation, migration, and invasion, and reduced HCC cellular apoptosis.
[Cell Death & Disease] |
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| Scientists investigate the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and extracellular matrix accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.
[Cell Proliferation] |
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| Researchers showed that an unanticipated severe tumor phenotype was contributed collectively by severe cholestasis, metabolic changes, upregulated cell cycle progression and disruption of circadian rhythm in mutant hepatocytes.
[Molecular Cancer Research] |
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| Investigators presented a 3D in vitro microtissue model that used spheroidal, scaffold free co-culture of primary human hepatocytes, Kupffer cells, liver endothelial cells and hepatic stellate cells.
[Scientific Reports] |
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| The authors showed that in mice and humans there was a spliced variant of p65, named p65 iso5, which bound the corticosteroid hormone dexamethasone amplifying the effect of the glucocorticoid receptor and was expressed in the liver of patients with hepatic cirrhosis and hepatocellular carcinoma.
[Scientific Reports] |
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| Scientists showed that remimazolam could attenuate inflammatory response in sepsis-associated acute liver injury, which may have been associated with activation of peripheral benzodiazepine receptors and inhibition of p38 phosphorylation in macrophages.
[International Immunopharmacology] |
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| RNA sequencing of liver tissue showed that the expression of SCD1 increased significantly in chronic periodontitis rats compared to controls. KEGG enrichment analysis showed that the AMPK signalling pathway may have been involved in liver steatosis.
[Life Sciences] |
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| A higher matrix stiffness equipped tumor cells with enhanced stemness and proliferative characteristics, which was dependent on the activation of integrin β1/FAK/ERK1/2/NF-κB signaling pathway.
[BMC Cancer] |
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| Researchers investigated the functional role of glycogen synthase 2 in the progression of intrahepatic cholangiocarcinoma and explored the underlying mechanism.
[Bioengineered] |
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| Scientists summarize the role of macrophages, platelets and neutrophils in liver ischaemia–reperfusion injury (LIRI), highlight unanswered questions, and discuss prospects for innovative therapeutic regimens against LIRI in transplant recipients.
[Nature Reviews Gastroenterology & Hepatology] |
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| The authors review bile acid signaling in liver, metabolic tissues, and the cardiovascular system, and propose the development of ligands to limit side effects and effectively manage the liver and cardiovascular components of non-alcoholic fatty liver disease.
[Trends in Molecular Medicine] |
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| Investigators suggest that inter-organ communication on the level of stem progenitor cells-HSTCs and ASCs could represent a key mechanism involved in controlling glucose tolerance as well as insulin sensitivity.
[Stem Cell Reviews and Reports] |
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| Vipergen announced the signing of a multi-target drug discovery agreement with Aligos Therapeutics, Inc. Aligos will select hits for development into novel therapeutics for viral and liver diseases.
[Vipergen] |
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| Gilead Sciences, Inc. announced that it submitted a Biologics License Application to the US FDA for bulevirtide for injection, a potential first-in-class antiviral medicine for the treatment of chronic hepatitis delta virus infection in adults with compensated liver disease.
[Gilead Sciences, Inc.] |
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| Revive Therapeutics Ltd. announced that it has filed an application with the US FDA to receive Orphan Drug Designation for Bucillamine for the prevention of ischemia–reperfusion injury during liver transplantation.
[Revive Therapeutics Ltd.] |
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| January 9 – 12, 2022
Portland, Oregon, United States |
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| | Accession Therapeutics – Oxford, England, United Kingdom |
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| KU Leuven – Leuven, Belgium |
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| | Emory University – Atlanta, Georgia, United States |
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| | German Research Center for Environmental Health – Oberschleißheim, Germany |
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| | Uppsala University – Uppsala, Sweden |
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