Hepatic Cell News Volume 5.45 | Dec 3 2021

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    2021-12-03 | HCN 5.45


    Hepatic Cell News by STEMCELL Technologies
    Vol. 5.45 – 3 December, 2021
    TOP STORY

    Fis1 Phosphorylation by Met Promotes Mitochondrial Fission and Hepatocellular Carcinoma Metastasis

    Researchers found that fragmented mitochondria fueled actin filament remodeling and lamellipodia or invadopodia formation to facilitate cell metastasis in hepatocellular carcinoma cells both in vitro and in vivo.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    GP73 Is a TBC-Domain Rab GTPase-Activating Protein Contributing to the Pathogenesis of Non-Alcoholic Fatty Liver Disease without Obesity

    Investigators showed GP73, a Golgi protein upregulated in livers from patients with a variety of liver diseases, exhibited Rab GTPase-activating protein activity regulating ApoB export.
    [Nature Communications]

    Full Article

    Dyrk1b Promotes Hepatic Lipogenesis by Bypassing Canonical Insulin Signaling and Directly Activating mTORC2 in Mice

    Scientists provided new insights into the mechanisms that underlie Dyrk1b-induced hepatic lipogenesis and hepatic insulin resistance and identified Dyrk1b as a therapeutic target for non-alcoholic liver steatohepatitis and insulin resistance in the liver.
    [Journal of Clinical Investigation]

    AbstractFull Article

    Bcl-3 Promotes TNF-Induced Hepatocyte Apoptosis by Regulating the Deubiquitination of RIP1

    Researchers demonstrated a crucial role of Bcl-3, an IκB family member, in regulating tumor necrosis factor-α (TNF)-induced hepatic cell death.
    [Cell Death & Differentiation]

    Full Article

    Mesenchymal Stromal Cells Mitigate Liver Damage after Extended Resection in the Pig by Modulating Thrombospondin-1/TGF-β

    The authors suggested that mesenchymal stromal cells ameliorated surgery-induced hepatocellular stress and epithelial-mesenchymal transition, thus supporting epithelial integrity and facilitating regeneration.
    [NPJ Regenerative Medicine]

    Full Article

    ONECUT2 Facilitates Hepatocellular Carcinoma Metastasis by Transcriptionally Upregulating FGF2 and ACLY

    Investigators reported that transcription factor One Cut homeobox 2 (ONECUT2) functioned as an oncogene to facilitate hepatocellular carcinoma metastasis.
    [Cell Death & Disease]

    Full Article

    Initiation of Hepatic Stellate Cell Activation Extends into Chronic Liver Disease

    Scientists identified transcriptional programs of initiating and activated hepatic stellate cells by RNA sequencing, using in vitro and in vivo mouse models of fibrosis.
    [Cell Death & Disease]

    Full Article

    Centromere Protein F Promotes Progression of Hepatocellular Carcinoma through ERK and Cell Cycle-Associated Pathways

    Researchers examined the expression of all centromere proteins and their association with recurrence and survival of hepatocellular carcinoma patients using the global gene expression profile dataset established in their laboratory.
    [Cancer Gene Therapy]

    Full Article

    The Circular RNA circSLC7A11 Functions as a Mir-330-3p Sponge to Accelerate Hepatocellular Carcinoma Progression by Regulating Cyclin-Dependent Kinase 1 Expression

    Northern blotting, quantitative real-time polymerase chain reaction, nucleocytoplasmic fractionation, and fluorescence in situ hybridization analyses were conducted to evaluate the expression and localization of circSLC7A11 in hepatocellular carcinoma tissues and cells.
    [Cancer Cell International]

    Full Article

    PCBP1 Regulates the Transcription and Alternative Splicing of Metastasis-Related Genes and Pathways in Hepatocellular Carcinoma

    The authors obtained and analyzed PCBP1-knockdown RNA-seq data and eCLIP-seq data of PCBP1 in HepG2 cells and found that PCBP1 widely regulated the alternative splicing and expression of genes enriched in cancer-related pathways.
    [Scientific Reports]

    Full Article

    Structural Changes and Expression of Hepatic Fibrosis-Related Proteins in Coculture of Echinococcus multilocularis Protoscoleces and Human Hepatic Stellate Cells

    Scientists investigated the role of Echinococcus multilocularis protoscoleces (PSCs) in hepatic fibrosis by examining structural changes and measuring hepatic fibrosis-related protein levels in cocultures of PSCs and human hepatic stellate cells.
    [Parasites & Vectors]

    Full ArticleGraphical Abstract

    Anti-Tumor Effect of Polysaccharide from Pleurotus ostreatus on H22 Mouse Hepatoma Ascites In Vivo and Hepatocellular Carcinoma In Vitro Model

    Administration of polysaccharide Pleurotus ostreatus showed a significant decrease in tumor cell metastasis while the increase in the survival period among mice models of H22 malignant ascites.
    [Amb Express]

    Full Article

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    REVIEWS

    Roles of IκB Kinases and TANK-Binding Kinase 1 in Hepatic Lipid Metabolism and Nonalcoholic Fatty Liver Disease

    The authors review the biochemical steps of hepatic lipid metabolism, dysregulated lipid metabolism in obesity and nonalcoholic fatty liver disease (NAFLD), and the roles of IκB kinase complexes and TANK-binding kinase 1 in obesity and NAFLD.
    [Experimental and Molecular Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Leronlimab (350 mg) Weekly Use for 14 Weeks in Open Label Arm of NASH Trial Produces Fibrosis Reduction as High as 93 Msec amongst First 15 Patients with Average Reduction of 24 Msec

    CytoDyn, Inc., a late-stage biotechnology company developing leronlimab, a CCR5 antagonist with the potential for multiple therapeutic indications, reported data from its trial treating nonalcoholic steatohepatitis (NASH) open-label with leronlimab.
    [CytoDyn, Inc.]

    Press Release

    Mount Sinai Researchers Awarded $3.15 Million to Advance a Multidisciplinary Drug Development Platform for Hepatocellular Carcinoma

    The National Cancer Institute has awarded Mount Sinai researchers $3.15 million in grant funding to assess the potential of a multidisciplinary drug development platform to identify new biological targets for precision-based therapeutics for hepatocellular carcinoma.
    [Mount SInai]

    Press Release

    FEATURED EVENT

    Immunometabolism at the Crossroads of Obesity and Cancer

    January 16 – 20, 2022
    Banff, Alberta, Canada

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    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Fatty Liver Disease and Metabolic Syndrome

    University of Gothenburg РG̦teborg, Sweden

    Researcher – Cell Biologist

    Accession Therapeutics – Oxford, England, United Kingdom

    Professor – Gut-Liver Axis

    KU Leuven – Leuven, Belgium

    Postdoctoral Fellow – Cell Biology And Genomics Of Liver Injury

    Emory University – Atlanta, Georgia, United States

    Postdoctoral Position – Cell Biology of Liver Metabolism

    German Research Center for Environmental Health – Oberschleißheim, Germany

    > See All Jobs

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