Hepatic Cell News Volume 6.00 | Jan 7 2022

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    2022-01-07 | HCN 6.00


    Hepatic Cell News by STEMCELL Technologies
    Vol. 6.00 – 7 January, 2022
    TOP STORY

    Proteogenomic Characterization Identifies Clinically Relevant Subgroups of Intrahepatic Cholangiocarcinoma

    The authors performed proteogenomic characterization of intrahepatic cholangiocarcinoma using paired tumor and adjacent liver tissues from 262 patients.
    [Cancer Cell]

    AbstractGraphical Abstract

    Free Wallchart: Dynamic Modeling in Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    CRISPR Screens Uncover Protective Effect of PSTK as a Regulator of Chemotherapy-Induced Ferroptosis in Hepatocellular Carcinoma

    CRISPR-based loss-of-function genetic screens were used to target 18,053 protein-coding genes in hepatocellular carcinoma cells to identify chemotherapy-related synthetic lethal genes in these cells.
    [Molecular Cancer]

    Full Article

    Hepatic IRF8 Expression Suppresses Hepatocellular Carcinoma Progression and Enhances the Response to Anti-PD-1 Therapy

    Scientists identified interferon regulatory factor (IRF8) as an important prognostic biomarker in hepatocellular carcinoma patients which predicted the response and sensitivity to anti-PD-1 therapy.
    [Hepatology]

    Abstract

    An Antisense Transcript Transcribed from Irs2 Locus Contributes to the Pathogenesis of Hepatic Steatosis in Insulin Resistance

    Researchers revealed a functional duality of the Irs2 gene locus, where reciprocal changes of Irs2 and ASIrs2 in obesity caused insulin resistance and steatosis.
    [Cell Chemical Biology]

    AbstractGraphical Abstract

    Nano Delivery of Simvastatin Targets Liver Sinusoidal Endothelial Cells to Remodel Tumor Microenvironment for Hepatocellular Carcinoma

    The effect of simvastatin on liver sinusoidal endothelial cells and hepatic stellate cells was examined by immunoblotting, quantitative RT-PCR and RNA-seq.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    Increased Mitochondrial Fission Drives the Reprogramming of Fatty Acid Metabolism in Hepatocellular Carcinoma Cells through Suppression of Sirtuin 1

    Investigators explored the role of increased mitochondrial fission in lipid metabolism in hepatocellular carcinoma cells.
    [Cancer Communications]

    Full Article

    FGF21 Alleviates Acute Liver Injury by Inducing the SIRT1-Autophagy Signaling Pathway

    Scientists verified the relationship among fibroblast growth factor 21 (FGF21), autophagy, and Sirtuin type 1 (SIRT1) in carbon tetrachloride-induced acute liver injury.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Deletion of kif3a in CK19 Positive Cells Leads to Primary Cilia Loss, Biliary Cell Proliferation and Cystic Liver Lesions in TAA-Treated Mice

    Biliary progenitor cells were isolated and grown as organoids from gallbladders. Cells and tissue were analyzed using histology, immunohistochemistry and Western blot assays.
    [Biochimica Et Biophysica Acta-Molecular Basis of Disease]

    Abstract

    Objective to Identify and Verify the Regulatory Mechanism of DTNBP1 as a Prognostic Marker for Hepatocellular Carcinoma

    The expression and prognostic value of DTNBP1 were investigated using the data from Cancer Genome Atlas database, Gene Expression Omnibus cohorts, and clinical samples.
    [Scientific Reports]

    Full Article

    Identification of the Critical Genes and miRNAs in Hepatocellular Carcinoma by Integrated Bioinformatics Analysis

    An integrative analysis of genes and miRNA for hepatocellular carcinoma (HCC) was conducted to unravel the potential prognosis of HCC. A total of 177 differently expressed genes and 80 differently expressed miRNAs were screened out.
    [Medical Oncology]

    Abstract

    Galactose-Decorated Liver Tumor-Specific Nanoliposomes Incorporating Selective BRD4-Targeted PROTAC for Hepatocellular Carcinoma Therapy

    Researchers suggested that galactosylated nanoliposomes incorporating ARV-825 was a novel actively targeted PROTAC-based nanotherapeutic approach for hepatocellular carcinoma.
    [Heliyon]

    Full ArticleGraphical Abstract

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    REVIEWS

    Severe Hypoxia Is a Typical Characteristic of Human Hepatocellular Carcinoma: Scientific Fact or Fallacy?

    The authors demonstrate how overinterpretation of in vitro experiments and incorrect citations have resulted in hepatocellular carcinomas being perceived as severely hypoxic tumors.
    [Journal of Hepatology]

    Full Article

    The Role of Mesenchymal Stem Cells in the Occurrence, Development, and Therapy of Hepatocellular Carcinoma

    Investigators analyzed the role of mesenchymal stem cells (MSCs) in the tumor microenvironment and summarized the relationship between MSCs and liver cancer stem cells.
    [Cancer Medicine]

    Full Article

    Long Non-Coding RNA Small Nucleolar RNA Host Genes: Functions and Mechanisms in Hepatocellular Carcinoma

    Scientists review the mechanism and signaling pathway of small nucleolar RNA host gene in hepatocellular carcinoma (HCC), which provides a theoretical basis for the clinical treatment of HCC.
    [Molecular Biology Reports]

    Abstract

    INDUSTRY AND POLICY NEWS

    Novartis Announces Collaboration with Alnylam to Explore Targeted Therapy to Restore Liver Function

    Novartis announced a collaboration with Alnylam to leverage Alnylam’s proprietary siRNA technology to inhibit a target discovered at the Novartis Institutes for BioMedical Research, potentially leading to the development of a treatment designed to promote the regrowth of functional liver cells.
    [Novartis]

    Press Release

    FEATURED EVENT

    Advances in Checkpoints Immunology from Autoimmunity to Oncology of Infectious Diseases

    February 6 – 10, 2022
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Liver Injury and Fibrosis

    Stanford University – Stanford, California, United States

    Postdoctoral Position – Regulation of Hepatic Chromatin Organization

    University of Southern Denmark – Odense M, Denmark

    Postdoctoral Fellowship – Fatty Liver Disease and Metabolic Syndrome

    University of Gothenburg РG̦teborg, Sweden

    Researcher – Cell Biologist

    Accession Therapeutics – Oxford, England, United Kingdom

    > See All Jobs

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