 | | Vol. 6.01 – 14 January, 2022 |
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| By integrating multi-omic datasets, investigators provided validated strategies to reliably discriminate and localize all hepatic cells, including a population of lipid-associated macrophages at the bile ducts.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed a Sleeping Beauty transposon-based in vivo insertional mutagenesis screen in liver-specific Pten-deficient mice and identified tumor necrosis factor receptor-related factor 3 (Traf3) as the most significantly mutated gene in murine intrahepatic cholangiocarcinomas in a loss-of-function manner.
[Hepatology] |
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| The authors identified a subgroup of combined hepatocellular (HCC)-cholangiocarcinoma that displayed features of an ongoing intratumor immune response, along with an activation of gene signatures predictive of response to immunotherapy in HCC.
[Clinical Cancer Research] |
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| Researchers investigated the molecular mechanisms that determined intercellular adhesion receptor (ICAM)-1 localization into apical membrane domains of polarized hepatic epithelial cells, and their effect on lymphocyte-hepatic epithelial cell interaction.
[Cellular and Molecular Life Sciences] |
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| Scientists assessed the role of exosomes derived from recombination signal binding protein-Jκ (RBPJ)-overexpressed macrophages in hepatocellular carcinoma.
[Cell Death & Disease] |
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| Investigators reported the ability of estrogen receptor alpha (ERα) to transcriptionally inhibit G protein subunit alpha 12 (Gα12) responsible for hepatocellular carcinoma worsening.
[International Journal of Cancer] |
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| The authors investigated whether sapidolide A exerted protective effects on macrophages, thus alleviating the secondary hepatocyte damage in an acetaminophen-induced liver injury.
[Acta Pharmacologica Sinica] |
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| Researchers investigated whether tetramethylpyrazine exerted liver-protective action through regulating extracellular vesicle-dependent intercellular communication between hepatocytes and hepatic stellate cells.
[Acta Pharmacologica Sinica] |
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| Investigators revealed a continuous signaling pathway, MAPK p38-Ulk1 phosphorylation-Ulk1/Atg13 disruption, which inhibited autophagy and induced IL-1β expression in hepatic stellate cells.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| Researchers investigated the role and underlying molecule mechanism of very-long-chain acyl-CoA dehydrogenase (VLCAD) in the pathological process of hepatocellular carcinoma.
[Clinical and Translational Oncology] |
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| The authors discovered a conserved cancer-testis-long non-coding RNA which was highly expressed in the testes and hepatocellular carcinoma.
[Nature Cancer] |
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| Despite challenges related to efficacy, selectivity and safety, several new classes of synthetic de novo lipogenesis inhibitors have entered clinical-stage development and may become the foundation for a new class of therapeutics.
[Nature Reviews Drug Discovery] |
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| Scientists outline the evidence in support of neutrophils as drivers of hepatocellular carcinoma and detail their mechanistic roles in development, progression, and metastasis, highlighting the reasons that neutrophils are well worth investigating despite the challenges associated with studying them.
[Nature Reviews Gastroenterology & Hepatology] |
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| Exosome-derived non-coding RNAs have promising potential and clinical implications for the early diagnosis, targeted therapy, and prognosis of liver diseases.
[Laboratory Investigation] |
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| Aligos Therapeutics, Inc. announced that it has expanded its ongoing collaboration agreement with Merck to discover and develop oligonucleotide therapies for non-alcoholic steatohepatitis (NASH).
[Aligos Therapeutics, Inc.] |
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| COUR Pharmaceuticals announced the US FDA granted Fast Track Designation to the company’s investigational therapy CNP-104 for the treatment of primary biliary cholangitis.
[COUR Pharmaceuticals (PR Newswire, Inc.)] |
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| February 6-9, 2022
Keystone Resort, Colorado, United States |
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| | UK Research and Innovation – Oxfordshire, England, United Kingdom |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Stanford University – Stanford, California, United States |
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| | University of Southern Denmark – Odense M, Denmark |
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| | University of Gothenburg РG̦teborg, Sweden |
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