 | | Vol. 6.05 – 11 February, 2022 |
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| A novel ionizable lipidoid nanoparticle and a state-of-the-art lyophilization technology were developed, enabling to deliver small interfering RNA (siRNA) targeting apolipoprotein B into the hepatocytes with an ED50 of 0.05 mg/kg after intravenous injection.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Following the observation that caffeine (CF) reduced circulating PCSK9 levels and increased hepatic low-density lipoprotein receptor (LDLR) expression, additional CF-derived analogs with increased potency for PCSK9 inhibition compared to CF itself were developed.
[Nature Communications] |
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| The authors showed that ICl,SWELL and SWELL1 protein were reduced in adipose and β-cells in murine and human diabetes.
[Nature Communications] |
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| Scientists explored the genomic and molecular underpinnings of HCC with increased fluorine-18 fluorodeoxyglucose uptake in positron emission tomography (PET) and identified therapeutic targets based on this imaging-genomic surrogate.
[Clinical Cancer Research] |
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| Researchers observed unexpectedly high levels of hepatocyte heterogeneity in the developing liver and the progressive construction of the zonated metabolic functions from pericentral to periportal hepatocytes, which was orchestrated with the development of sinusoid endothelial, stellate, and Kupffer cells.
[Developmental Cell] |
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| To determine the role of programmed death-ligand 1 (PD-L1) in myofibroblastic activation of hepatic stellate cells (HSCs), investigators disrupted PD-L1 of HSCs by shRNA or anti-PD-L1 antibody.
[Cell Reports] |
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| Researchers found that discoidin domain receptor 1 (DDR1) was upregulated in HCC tissues, and the expression of DDR1 in TNM stage II-IV was higher than that in TNM stage I in HCC tissues, and high DDR1 expression was associated with poor prognosis.
[Oncogene] |
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| Phenazine biosynthesis-like domain-containing protein (PBLD) exerted an inhibitory effect on angiogenesis not only via blocking the VEGFR2 expression in endothelial cells, but also through downregulating HIF-1a-induced VEGF expression and secretion in hepatocellular carcinoma cells.
[Oncogene] |
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| Investigators confirmed that ETV4 was significantly upregulated by Hepatitis B virus X protein (HBx) and involved in super-enhancer-associated chromatin accessibility. Increased expression of ETV4 promoted HCC cell invasion and metastasis by upregulating DVL2.
[Cell Death & Disease] |
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| Scientists reported the mechanism by which signal transducer and activator of transcription 4 (stat4) rs7574865 promoted the occurrence and progression of HCC.
[Cell Death & Disease] |
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| The authors demonstrated that mono-2-ethylhexyl phthalate (MEHP) exposure inhibited the expression of STAT5A by causing oxidative damage in BRL-3A hepatocytes, thus accelerating the expression of key molecules in fibrosis and promoting the occurrence of liver fibrosis.
[Chemosphere] |
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| Investigators revealed that acidosis could significantly trigger fatty acid synthesis to promote liver tumorigenesis by upregulating SCD1 in a PI3K/AKT activation dependent manner and simultaneously promote SCD1 binding to PPARα.
[Molecular Cancer Research] |
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| Researchers observed the elevated expression of chemokine receptor 4 (CXCR4) in uveal melanoma (UM) patient liver tissues, and high CXCR4 expression in liver metastases of UM murine models, regardless of the expression levels in the primary tumors.
[Cancer Gene Therapy] |
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| Investigators discuss the relevance of promoting smoking cessation to improve rates of treatment response in clinical trials, fibrosis regression, risk of hepatocellular carcinoma, and liver transplant outcomes.
[Journal of Hepatology] |
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| Scientists summarize the current trends and findings of the altered lipidomic landscape of HCC and discuss their potential biological significance for hepatocarcinogenesis.
[Seminars in Cancer Biology] |
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| The authors discuss current knowledge about the biogenesis of exosomal miRNA and exosome-mediated microRNA transfer and review the potential of exosomal miRNA in diagnosis and therapeutics of nonalcoholic fatty liver disease.
[Journal of Cellular Physiology] |
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| University of Washington bioengineer Kelly Stevens, whose research focuses on mapping human organs and engineering artificial human tissues, has received an Allen Distinguished Investigator Award to support her work to map and understand how human livers develop.
[University of Washington Department of Bioengineering] |
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| April 6 – 9, 2022
Heidelberg, Germany |
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| | Columbia University – New York, New York, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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| | Mayo Clinic – Rochester, Minnesota, United States |
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