 | | Vol. 6.06 – 18 February, 2022 |
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| Volumetric bioprinting via optical tomography shaped organoid-laden gelatin hydrogels into complex centimeter-scale 3D structures in under 20 seconds.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that carnitine palmitoyltransferase 1A expression was elevated in hepatic stellate cells of patients with non-alcoholic steatohepatitis, showing a positive correlation with the fibrosis score.
[Journal of Hepatology] |
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| Scientists elucidated the nature, regulation and functional relevance of PD-L1+ host cells in HCC.
[Gut] |
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| Researchers suggested that KIRREL1 functioned as a feedback regulator of the mammalian Hippo pathway through sensing cell-cell interaction and recruiting SAV1 to cell-cell contact sites.
[Nature Communications] |
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| Investigators showed that macropinocytosis occurred universally in HCC under hypoxia. HIF-1 activated the transcription of a membrane ruffling protein, EH domain-containing protein 2, to initiate macropinocytosis.
[Nature Communications] |
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| A physiologically relevant human vascularized liver model was bioprinted with a novel liver extracellular matrix-based bioink laden with human adipose mesenchymal stem cell-derived hepatocyte-like cells, human umbilical vein endothelial cells, and human hepatic stellate cells.
[ACS Applied Materials & interfaces] |
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| In vitro and in vivo experiments suggested that ubiquitin-conjugating enzyme E2T (UBE2T) promoted HCC development including proliferation and metastasis.
[Cell Death & Disease] |
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| In hepatic cells, Dicer deletion delivered distinct lipid profile and increased lipid oxidation. Mechanically, Dicer deletion caused declined miR-192-3p and increased IGF2 in hepatocytes.
[Cancer Gene Therapy] |
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| Researchers found that Circ_0003945 was upregulated in HCC tissue, and higher Circ_0003945 expression was positively correlated with tumour size and tumor stage.
[Journal of Cellular and Molecular Medicine] |
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| To improve the effectiveness of naïve hair follicle-derived-MSC (HF-MSC) treatments on liver cirrhosis (LC), the authors used bioinformatic tools to identify an exogenous gene targeting hepatic stellate cells (HSCs) among the differentially expressed genes in LC to modify HF-MSCs.
[Cell Death Discovery] |
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| Scientists investigated the mechanisms underlying the protective effect of glucagon-like peptide-1 receptor (GLP-1R) on non-alcoholic fatty liver disease using an in vitro model of steatosis treated with the GLP-1R agonist Exendin-4.
[Scientific Reports] |
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| Researchers identified 130 genes significantly differentially expressed in non-alcoholic steatohepatitis (NASH) versus a mixed group of non-alcoholic fatty liver disease and healthy controls.
[Scientific Reports] |
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| Investigators studied the metabolic effect of resveratrol around the circadian clock in order to determine more accurately the hepatic signaling pathways involved. AML-12 hepatocytes were treated with resveratrol and clock and metabolic markers were measured around the clock.
[Plant Foods For Human Nutrition] |
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| The authors provide a summary of the role of bile acids (BAs) and their disrupted homeostasis in the development of gastrointestinal and hepatic disorders and present novel insights on how targeting BA pathways might contribute to novel treatment strategies for these disorders.
[Nature Reviews Gastroenterology & Hepatology] |
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| Scientists introduce the current knowledge about extracellular vesicles (EVs) and how they operate to maintain a healthy liver microenvironment, then summarize some of the aberrant observations reported on HCC-derived EVs and how they contribute to HCC pathogenesis.
[Seminars in Cancer Biology] |
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| Investigators focus on the potential role of growth hormone and insulin-like growth factor I in the regulation of hepatic steatosis, inflammation, and fibrosis.
[Journal of Clinical Endocrinology & Metabolism] |
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| Revive Therapeutics Ltd. announced that the US FDA has granted Orphan Drug Designation for Bucillamine for the prevention of ischemia–reperfusion injury during liver transplantation.
[Revive Therapeutics Ltd.] |
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| Axcella Therapeutics announced that the US FDA has granted a Fast Track Designation to AXA1125 for the treatment of non-alcoholic steatohepatitis (NASH) with liver fibrosis.
[Axcella Therapeutics] |
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| March 20 – March 25 |
Vienna, Austria |
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| | University Of Wisconsin–Madison – Madison, Wisconsin, United States |
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| | Columbia University – New York, New York, United States |
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| | University of Washington – Seattle, Washington, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Wayne State University School of Medicine – Detroit, Michigan, United States |
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