Hepatic Cell News Volume 6.09 | Mar 11 2022

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    2022-03-11 | HCN 6.09


    Hepatic Cell News by STEMCELL Technologies
    Vol. 6.09 – 11 March, 2022
    TOP STORY

    Regulation of Liver Subcellular Architecture Controls Metabolic Homeostasis

    Investigators found that the hepatic subcellular organization of the endoplasmic reticulum architecture were highly dynamic, integrated with the metabolic state and critical for adaptive homeostasis and tissue health.
    [Nature]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Transcriptional Switch of Hepatocytes Initiates Macrophage Recruitment and T Cell Suppression in Endotoxemia

    Scientists identified a proinflammatory hepatocyte subpopulation that developed primarily from periportal hepatocytes and to a lesser extent from pericentral hepatocytes and played key immunoregulatory roles in endotoxemia.
    [Journal of Hepatology]

    Full ArticleGraphical Abstract

    Circ-ZEB1 Promotes PIK3CA Expression by Silencing miR-199a-3p and Affects the Proliferation and Apoptosis of Hepatocellular Carcinoma

    Whole-genome sequencing revealed that circ-ZEB1 and PIK3CA were highly expressed in HCC tissues, whereas miR-199a-3p was significantly downregulated in HCC.
    [Molecular Cancer]

    Full Article

    KLF15 Cistromes Reveal a Hepatocyte Pathway Governing Plasma Corticosteroid Transport and Systemic Inflammation

    The authors showed that hepatocyte Kruppel-like factor 15 (KLF15) controlled plasma corticosteroid transport and inflammatory responses through direct transcriptional activation of Serpina6, which encoded corticosteroid-binding globulin.
    [Science Advances]

    Full Article

    Ubiquitin Ligase E3 HUWE1/MULE Targets Transferrin Receptor for Degradation and Suppresses Ferroptosis in Acute Liver Injury

    Researchers found that deficiency of Huwe1 in mice hepatocytes exacerbated ischemia-reperfusion injury and CCl4-induced liver injury with more ferroptosis occurrence, and that suppression of Huwe1 enhanced cellular sensitivity to ferroptosis in primary hepatocytes and mouse embryonic fibroblasts.
    [Cell Death & Differentiation]

    Abstract

    Defining the Mammalian Coactivation of Hepatic 12 Hour Clock and Lipid Metabolism

    Investigators showed that steroid receptor coactivator steroid receptor coactivator 3 coactivated X-box-binding protein-1 transcription and regulated hepatic 12 hour cistrome and gene rhythmicity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Activation of the Notch1-C-Myc-VCAM1 Signaling Axis Initiates Liver Progenitor Cell-Driven Hepatocarcinogenesis and Pulmonary Metastasis

    Scientists discovered that the Notch1-c-myc-VCAM1 signaling axis initiated liver progenitor cell-driven hepatocarcinogenesis and metastasis, providing a preclinical model for HCC study.
    [Oncogene]

    Abstract

    Sestrin2 Protects against Cholestatic Liver Injury by Inhibiting Endoplasmic Reticulum Stress and NLRP3 Inflammasome-Mediated Pyroptosis

    Researchers investigated the role of hepatic Sestrin2 in cholestatic liver injury and its underlying mechanisms using in vivo and in vitro approaches.
    [Experimental and Molecular Medicine]

    Full Article

    Rcl1 Suppresses Tumor Progression of Hepatocellular Carcinoma: A Comprehensive Analysis of Bioinformatics and In Vitro Experiments

    RNA 3’-terminal phosphate cyclase-like protein (RCL1) expression was commonly down-regulated in HCC. The lower expression of RCL1 was associated with higher tumor stage, higher AFP level, vascular invasion, and poor prognosis.
    [Cancer Cell International]

    Full Article

    LncRNA MEG3 Up-Regulates SIRT6 by Ubiquitinating EZH2 and Alleviates Nonalcoholic Fatty Liver Disease

    Scientists presented the significant role of a novel signaling axis comprising long non-coding RNA maternally expressed gene 3 (MEG3), enhancer of zeste homolog 2 (EZH2), and sirtuin 6 (SIRT6) in controlling lipid accumulation, inflammation, and the progression of nonalcoholic fatty liver disease.
    [Cell Death Discovery]

    Full Article

    WWP1 Upregulation Predicts Poor Prognosis and Promotes Tumor Progression by Regulating Ubiquitination of NDFIP1 in Intrahepatic Cholangiocarcinoma

    The authors investigated the expression pattern, clinical prognosis, tumor biological functions, and molecular mechanisms of WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) in intrahepatic cholangiocarcinoma.
    [Cell Death Discovery]

    Full Article

    Clitorin Ameliorates Western Diet-Induced Hepatic Steatosis by Regulating Lipogenesis and Fatty Acid Oxidation In Vivo and In Vitro

    Researchers investigated the inhibitory effects and underlying governing mechanism of clitorin in a western diet-induced hepatic steatosis mouse model, and in oleic acid-stimulated HepG2 cells.
    [Scientific Reports]

    Full Article

    Immune-Related lincRNA Pairs Predict Prognosis and Therapeutic Response in Hepatocellular Carcinoma

    Scientists utilized the strategy of iterative gene pairing to construct a tumor-specific immune-related long intergenic noncoding RNA (lincRNA) pairs signature, which did not require specific expression levels, as an indicator of patient outcomes.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Mutational Signatures and Processes in Hepatobiliary Cancers

    Exploiting mutational signatures to retrospectively understand hepatobiliary carcinogenesis could advance preventative management of these aggressive tumors as well as potentially predict treatment response and guide the development of therapies targeting tumour evolution.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    mRNA & Gene Editing Late Breaking Therapies in Liver Diseases

    Investigators summarize the preclinical data obtained in animal models treated with mRNA as a therapeutic agent and discuss the different gene editing strategies applied to the treatment of liver diseases, highlighting both their therapeutic efficacy as well as safety concerns.
    [Hepatology]

    Abstract

    Neoadjuvant Approaches in Hepatocellular Carcinoma: There’s No Time like the Present

    The authors appraise the existing literature and current clinical trial landscape of neoadjuvant therapies in HCC.
    [Clinical Cancer Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    Inventiva Announces That Its IND Application for the Phase II Combination Trial with Lanifibranor and Empagliflozin in Patients with NASH and T2D Has Been Accepted by the FDA

    Inventiva announced that the US FDA has concluded that its lead drug candidate lanifibranor and the SGLT2 inhibitor empagliflozin1 in patients with type 2 diabetes (T2D) and non-cirrhotic non-alcoholic steatohepatitis (NASH) may proceed.
    [Inventiva]

    Press Release

    FEATURED EVENT

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    Apr 27 – May 1, 2022
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    JOB OPPORTUNITIES

    Senior Associate Scientist – Biology

    Gilead Sciences – Foster City, California, United States

    Postdoctoral Scientist – Liver Resident Memory T Cell

    Amsterdam UMC – Amsterdam, Netherlands

    Postdoctoral Fellow – Diabetes, Cardiovascular Disorders and Non-Alcoholic Steatohepatitis

    NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States

    Research Scientist – HBV Cure

    Gilead Sciences, Inc. – Foster City, California, United States

    Postdoctoral Research Scientist – Immune Regulation

    Columbia University – New York, New York, United States

    > See All Jobs

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