 | | Vol. 6.12 – 1 April, 2022 |
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| Researchers performed single-cell RNA-sequencing using AKT/NICD-induced mouse intrahepatic cholangiocarcinoma tissues at early, middle, and late stages.
[Hepatology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that the nuclear factor HMGB1 acted as a strong repressor of liver lipogenesis.
[Science Advances] |
| | A stearoyl-CoA desaturase 1 (SCD1)-dependent mechanoresponsive pathway that responded to increasing matrix stiffness in the tumor microenvironment promoted HCC invasion and metastasis through lipid metabolic reprogramming.
[Molecular Therapy] |
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| To obtain a better appreciation of the molecular processes during the differentiation of induced pluripotent stem cells into hepatocytes, researchers employed a quantitative proteomic approach to follow the expression of 9,000 proteins, 12,000 phosphorylation sites, and 800 acetylation sites over time.
[Cell Reports] |
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| The authors showed that in response to extensive hepatocyte damages, expression of dnmt1 was upregulated in biliary epithelial cells (BECs) to methylate DNA at the p53 locus, which repressed p53 transcription, and in turn, derepressed mTORC1 signaling to activate BEC dedifferentiation.
[NPJ Regenerative Medicine] |
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| The inhibitory effect of Selenoprotein S (SelS) on hepatic steatosis and insulin resistance was confirmed by SelS overexpression in primary hepatocytes in vitro.
[Cell Death & Disease] |
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| Employing a combination of chimeric lineage tracing, immunofluorescence, and immunohistochemistry, the authors demonstrated that Sox9+HNF4α+ hepatocytes, generated by transition from mature hepatocytes, played an important role in the initial phase after partial hepatectomy.
[Cell Death & Disease] |
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| Researchers engineered cell sheets to develop a new in vitro model of ballooned hepatocytes.
[Scientific Reports] |
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| The authors studied that intra-hepatic bile duct cells could be grown using a human liver organoid platform.
[Scientific Reports] |
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| Scientists discuss the epigenetic landscape in hepatocarcinogenesis, including evidence on the diagnostic and prognostic role of non-coding RNAs, modifications occurring at the chromatin level, and their role in the era of precision medicine.
[Journal of Experimental & Clinical Cancer Research] |
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| Galecto, Inc. announced it has completed enrollment in parts two and three of its ongoing 3-part Phase Ib/IIa trial of GB1211, GULLIVER-2, in liver cirrhosis.
[Galecto, Inc.] |
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| Albireo Pharma, Inc. announced the completion of patient enrollment in the ASSERT study, a Phase III pivotal trial of Bylvay in patients with Alagille syndrome.
[Albireo Pharma, Inc.] |
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| May 6 – May 10, 2022
Portland, Oregon, United States |
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| NIH National Institute on Alcohol Abuse and Alcoholism – Bethesda, Maryland, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Gilead Sciences – Foster City, California, United States |
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| | Amsterdam UMC – Amsterdam, Netherlands |
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