Hepatic Cell News Volume 6.15 | Apr 29 2022

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    2022-04-29 | HCN 6.15


    Hepatic Cell News by STEMCELL Technologies
    Vol. 6.15 – 29 April, 2022
    TOP STORY

    Targeting Anillin Inhibits Tumorigenesis and Tumor Growth in Hepatocellular Carcinoma via Impairing Cytokinesis Fidelity

    The proportion of cellular polyploidy decreases during HCC progression and Anillin actin binding protein level was significantly correlated with cellular polyploidy proportion in human HCC samples.
    [Oncogene]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Modulation of IL-36-Based Inflammatory Feedback Loop through Hepatocytes-Derived IL-36R-P2X7R Axis Improves Steatosis in Alcoholic Steatohepatitis

    Researchers elucidated the modulation of IL-36R-P2X7R-TLRs axis affected hepatocytes steatosis and IL-36-based inflammatory feedback loop that accompanied the onset of alcoholic steatohepatitis.
    [British Journal of Pharmacology]

    Abstract

    MyD88 in Hepatic Stellate Cells Enhances Liver Fibrosis via Promoting Macrophage M1 Polarization

    MyD88 signaling in HSCs increased the secretion of CXCL10, which promoted macrophage M1 polarization through CXCR3, leading to activation of the JAK/STAT1 pathway.
    [Cell Death & Disease]

    Full Article

    hMSCs-Derived Exosome circCDK13 Inhibits Liver Fibrosis by Regulating the Expression of MFGE8 through miR-17-5p/KAT2B

    Scientists investigated the effects of human bone marrow mesenchymal stem cells (hMSCs) -derived exosome circCDK13 on liver fibrosis and its mechanism.
    [Cell Biology and Toxicology]

    AbstractGraphical Abstract

    Apigenin Alleviated PA-Induced Pyroptosis by Activating Autophagy in Hepatocytes

    Researchers found for the first time that apigenin could alleviate palmitic acid (PA)-induced NLRP3 inflammasome activation and pyroptosis in HepG2 cells and primary mouse hepatic cells.
    [Food & Function]

    AbstractGraphical Abstract

    Chimeric HDAC and the Cytoskeleton Inhibitor Broxbam as a Novel Therapeutic Strategy for Liver Cancer

    In this study, scientists evaluated the potential suitability of broxbam for the treatment of liver cancer.
    [International Journal of Oncology]

    Abstract

    The Mouse Anxa6/miR-9-5p/Anxa2 Axis Modulates TGF-β1-Induced Mouse Hepatic Stellate Cell (mHSC) Activation and CCl4-Caused Liver Fibrosis

    HSC activation is a central event of hepatic fibrosis progression. In this study, the up-regulation of lncRNA ANXA2P2 was found in liver fibrosis.
    [Toxicology Letters]

    Full Article

    miR-4730 Suppresses the Progression of Liver Cancer by Targeting the High Mobility Group A1 Pathway

    The effects of miR‑4730 overexpression were examined in liver cancer cell lines, and the target genes of miR‑4730 were evaluated using microarray analysis and TargetScan data.
    [International Journal of Molecular Medicine]

    Abstract

    Hepatic Response to the Interaction between Thymoquinone and Iron-Dextran: An In Vitro and In Vivo Study

    Researchers evaluated the effect of thymoquinone on hepatotoxicity induced by iron-overload in in vitro and mouse model.
    [Biological Trace Element Research]

    Abstract

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    REVIEWS

    Molecular Pathogenesis and Systemic Therapies for Hepatocellular Carcinoma

    The authors discuss the molecular pathogenesis of hepatocellular carcinoma, molecular classes and determinants of heterogeneity.
    [Nature Cancer]

    Abstract

    INDUSTRY AND POLICY NEWS

    Galmed Reports Interim Results from the Open-Label Part of the ARMOR Study with Aramchol Showing Robust Fibrosis Improvement across Multimodality Histological Assessment

    Galmed Pharmaceuticals Ltd. announced interim results from the Open-Label Part of the ARMOR study showing fibrosis improvement with Aramchol using multimodality histological assessment.
    [Galmed Pharmaceuticals Ltd.]

    Press Release

    FEATURED EVENT

    Modern Phenotypic Drug Discovery – From Chemical Biology to Therapeutics

    May 22 – 25, 2022
    Denver, Colorado, United States

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    JOB OPPORTUNITIES

    Postdoctoral Position – Viral Hepatitis

    National Institute for Health and Medical Research – Strasbourg, France

    Postdoctoral Associate – Obesity Related Liver Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Molecular Biology

    City of Hope – Duarte, California, United States

    Postdoctoral Fellowship – In Vivo Cellular Imaging

    Johns Hopkins University – Baltimore, Maryland, United States

    Research Associate – Molecular Biology

    The University of British Columbia – Vancouver, British Columbia, Canada

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