| Vol. 6.15 – 29 April, 2022 |
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| The proportion of cellular polyploidy decreases during HCC progression and Anillin actin binding protein level was significantly correlated with cellular polyploidy proportion in human HCC samples. [Oncogene] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers elucidated the modulation of IL-36R-P2X7R-TLRs axis affected hepatocytes steatosis and IL-36-based inflammatory feedback loop that accompanied the onset of alcoholic steatohepatitis. [British Journal of Pharmacology] |
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| MyD88 signaling in HSCs increased the secretion of CXCL10, which promoted macrophage M1 polarization through CXCR3, leading to activation of the JAK/STAT1 pathway. [Cell Death & Disease] |
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| Scientists investigated the effects of human bone marrow mesenchymal stem cells (hMSCs) -derived exosome circCDK13 on liver fibrosis and its mechanism. [Cell Biology and Toxicology] |
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| Researchers found for the first time that apigenin could alleviate palmitic acid (PA)-induced NLRP3 inflammasome activation and pyroptosis in HepG2 cells and primary mouse hepatic cells. [Food & Function] |
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| In this study, scientists evaluated the potential suitability of broxbam for the treatment of liver cancer. [International Journal of Oncology] |
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| HSC activation is a central event of hepatic fibrosis progression. In this study, the up-regulation of lncRNA ANXA2P2 was found in liver fibrosis. [Toxicology Letters] |
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| The effects of miR‑4730 overexpression were examined in liver cancer cell lines, and the target genes of miR‑4730 were evaluated using microarray analysis and TargetScan data. [International Journal of Molecular Medicine] |
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| Researchers evaluated the effect of thymoquinone on hepatotoxicity induced by iron-overload in in vitro and mouse model. [Biological Trace Element Research] |
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| The authors discuss the molecular pathogenesis of hepatocellular carcinoma, molecular classes and determinants of heterogeneity. [Nature Cancer] |
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| Galmed Pharmaceuticals Ltd. announced interim results from the Open-Label Part of the ARMOR study showing fibrosis improvement with Aramchol using multimodality histological assessment. [Galmed Pharmaceuticals Ltd.] |
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| May 22 – 25, 2022 Denver, Colorado, United States |
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| National Institute for Health and Medical Research – Strasbourg, France |
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| Baylor College of Medicine – Houston, Texas, United States |
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| City of Hope – Duarte, California, United States |
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| Johns Hopkins University – Baltimore, Maryland, United States |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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