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DNA Hypermethylation Modification Promotes the Development of Hepatocellular Carcinoma by Depressing the Tumor Suppressor Gene ZNF334 | Researchers reported significant differences in the DNA methylation spectrum among the three types of tissues.
[Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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Opposing Roles of HDAC6 in Liver Regeneration and Hepatocarcinogenesis | HDAC6 ablation induced cellular senescence in primary MEFs and inhibited cell proliferation in HepG2 cells and liver regeneration after 2/3 partial hepatectomy.
[Cancer Science] |
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Activated AXL Protects against Hepatic Ischemia-Reperfusion Injury by Upregulating SOCS-1 Expression | RAXL activation protected the liver from ischemia-reperfusion injury by upregulating SOCS-1 and inhibiting the toll-like receptor 4/myeloid differentiation factor-88/nuclear factor kappa-B signaling axis.
[Transplantation] |
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Modification of Lysine Deacetylation Regulates Curcumol-Induced Necroptosis through Autophagy in Hepatic Stellate Cells | Scientists indicated that curcumol activated Sirt1 to promote Atg5 deacetylation and enhanced its protein–protein interaction function, thereby inducing autophagy and promoting the necroptosis of hepatic stellate cells to reduce liver fibrosis.
[Phytotherapy Research] |
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Versican Secreted by Cancer-Associated Fibroblasts Is a Poor Prognostic Factor in Hepatocellular Carcinoma | Researchers identified cancer-associated fibroblasts-specific proteins in HCC and determine whether they could be potential therapeutic targets.
[Annals of Surgical Oncology] |
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The Bromodomain Inhibitor JQ1 Up-Regulates the Long Non-Coding RNA MALAT1 in Cultured Human Hepatic Carcinoma Cells | Scientists reported that in HepG2 cells, JQ1 significantly reduced various proliferation-related lncRNAs, but up-regulated the known liver tumor marker, MALAT1.
[Scientific Reports] |
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Melatonin Relieves Liver Fibrosis Induced by Txnrd3 Knockdown and Nickel Exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-β1 Axis Activation | Melatonin exerted its antioxidant effects directly through its ability to clear free radicals and protected the liver from oxidative damage.
[Life Sciences] |
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Ochratoxin a Induces Hepatic Fibrosis through TGF-β Receptor I/Smad2/3 Signaling Pathway | The authors explored whether the TGF-β receptor I/Smad2/3 signaling pathway was related to epithelial–mesenchymal transition-induced hepatic fibrosis.
[Environmental Toxicology] |
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LIM Protein Ajuba Promotes Liver Cell Proliferation through Its Involvement in DNA Replication and DNA Damage Control | Researchers reported that in the liver, Ajuba expression was increased during regeneration and in tumor cells and tissues.
[Febs Letters] |
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Evaluation of HZX-960, a Novel DCN1-UBC12 Interaction Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis | Researchers identified that HZX-960 treatment could attenuate TGFβ-induced liver fibrotic responses by reducing the deposition of collagen I and α-SMA, and upregulating cellular NRF2, HO-1 and NQO1 level in two hepatic stellate cell lines.
[Biochemistry and Cell Biology] |
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Management of Hepatic Encephalopathy Associated with Advanced Liver Disease | Recent advances in the pathophysiology of hepatic encephalopathy identifying important key players such as interorgan ammonia metabolism and inflammation has set the basis for new therapies.
[Clinical Drug investigation] |
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Reimbursement Established for Lung and Liver Transplant in the Netherlands Based on Results from Clinical Trials with XVIVO’s Leading Technologies | Machine perfusion for lungs and livers is being reimbursed in the Dutch healthcare system. The Netherlands has a pronounced evidence-based healthcare system. Therefore, if a treatment option is proven beneficial for patients the government is likely to approve reimbursement.
[BioSpace] |
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| May 22 – 25, 2022
Denver, Colorado, United States |
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| The Research Institute at Nationwide Children’s Hospital – Columbus, Ohio, United States |
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| University of Gothenburg – Gothenburg, Sweden |
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| National Institute for Health and Medical Research – Strasbourg, France |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Johns Hopkins University – Baltimore, Maryland, United States |
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