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| Researchers generated human pluripotent stem cell (hPSC)-derived hepatic organoids (hHOs) with a high drug metabolic ability. They established a two-step protocol to produce hHOs from human pluripotent stem cells for long-term expansion and drug testing.
[Biomaterials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Bioinformatics analysis of the TCGA dataset wasused to identify the function and mechanism of TROY. Spheroid, apoptosis, and ALDH assay were performed to evaluate the stemness functions.
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists identified a mechanism by which cancer-associated fibroblasts-derived chemokine CCL5 enhanced HCC metastasis by triggering the HIF1α/ZEB1 axis.
[Cell Death & Disease] |
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| Investigators developed a co-culture method with patient-derived cholangiocarcinoma organoids and immune cells, which could represent anti-cancer immunity in vitro.
[British Journal of Cancer] |
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| HepG2-TRβ cells were treated with bovine serum albumin-conjugated palmitic acid to mimic lipotoxic conditions in vitro.
[Thyroid] |
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| The authors analyzed the hepatotoxicity of fructose in steatosis. Fructose effects on lipotoxicity were evaluated in HepG2 cells, primary mouse hepatocytes, and in mice fed a high-fat diet with or without sucrose.
[Journal of Nutritional Biochemistry] |
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| Cells grown in 3D cultures were sensitive to the oxidative phosphorylation inhibitor nitazoxanide, sorafenib, and regorafenib and resistant to other multikinase inhibitors and chemotherapeutic drugs.
[Scientific Reports] |
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| Scientists applied novel proteomic techniques to evaluate the interactions of hepatocyte nuclear factor 4α (HNF4α), including those with biochemically labile binding proteins.
[Biochemical and Biophysical Research Communications] |
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| The authors assessed five different nanobiomaterials (NBMd) formulations, including a bio-persistent gold nanoparticle, an IR-780 dye-loaded liposome which is used in deep tissue imaging, an unloaded PACA polymeric nanoparticle used as a drug delivery system (PACA) polymeric nanoparticle used as a drug delivery system, and two loaded PACA NBMs.
[Drug Delivery and Translational Research] |
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| Scientists review recent findings on the roles of yes-associated protein and PDZ-binding motif in non-neoplastic liver diseases and discuss directions for future research.
[Biomedicine & Pharmacotherapy] |
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| Numerous advances in systemic therapies have emerged in the last five years to fulfill the unmet needs of effective therapeutic options.
[Asia-Pacific Journal of Clinical Oncology] |
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| In a rare win for the difficult field of nonalcoholic steatohepatitis (NASH) drug development, Pfizer has been granted a fast-track ticket for two experimental therapies.
[Fierce Biotech] |
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| June 20 – 23, 2022
Seville, Spain |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| University of Gothenburg – Gothenburg, Sweden |
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| National Institute for Health and Medical Research – Strasbourg, France |
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