 | | Vol. 6.33 – 9 September, 2022 |
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| Scientists used single-cell transcriptomic techniques to analyze resected human pediatric hepatoblastoma specimens, and identified five hepatoblastoma tumor signatures that may have accounted for the tumor heterogeneity observed in this disease.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers analyzed trans-omic data in hepatocyte maturation and hepatic reprogramming of human dermal fibroblasts, uncovering five kinases as regulators in the two processes.
[Nature Communications] |
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| Investigators revealed that isoginkgetin (ISO) effectively inhibited HCC proliferation and migration in vitro. LC3-II expression and autophagosomes were increased under ISO treatment.
[Autophagy] |
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| ATP-binding cassette transporter B1 (ABCB1) was activated by epidermal growth factor receptor (EGFR) in a lipid raft-dependent manner, which enhanced the exocytosis of lenvatinib to mediate resistance.
[Cancer Research] |
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| The authors investigated the identification of extended-synaptotagmin 1, an endoplasmic reticulum (ER)-bound protein, as a key mediator for cytosolic protein secretion at the ER–plasma membrane contact sites.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Erastin-treated L-O2 hepatocytes were transfected with glutathione peroxidase 4 (GPx4) or nuclear factor erythroid 2-related factor 2 (Nrf2) siRNA to delineate the pathway of bicyclol against ferroptosis in vitro.
[Cell Death & Disease] |
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| Researchers present an induced pluripotent stem cell (iPSC)-derived hepatocyte-like cell platform to define the hepato-intrinsic response to Ebola virus infection.
[Stem Cell Reports] |
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| The authors review progress made over the past decade in the generation and use of stem cell-derived metabolic cell types and organoids in metabolic disease research, especially obesity and liver diseases.
[Nature Reviews Endocrinology] |
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| Scientists describe the physiological and analytical parameters that influence measurements of lipid flux and lipidomic patterns, and how these issues will propel the coming together of the two fields of metabolic tracing and lipidomics.
[Experimental and Molecular Medicine] |
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| Hepion Pharmaceuticals, Inc. announced that it has screened the first subject in the ASCEND-NASH clinical trial, a study to evaluate the safety and efficacy of rencofilstat in 336 subjects dosed for 12 months.
[Hepion Pharmaceuticals, Inc.] |
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| December 5 – 7, 2022
Virtual |
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| | University of California San Francisco – San Francisco, California, United States |
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| | Newcastle University – Newcastle Upon Tyne, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | BenevolentAI – Cambridge, England, UK |
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