Hepatic Cell News Volume 6.34 | Sep 16 2022

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    Laurisa Dohm
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    2022-09-16 | HCN 6.34


    Hepatic Cell News by STEMCELL Technologies
    Vol. 6.34 – 16 September, 2022
    TOP STORY

    Transcriptional Switch of Hepatocytes Initiates Macrophage Recruitment and T Cell Suppression in Endotoxemia

    The spatial and temporal changes in hepatocytes and non-parenchymal cell types were validated by multiplex immunofluorescence staining, bulk transcriptomic sequencing, or flow cytometry.
    [Journal of Hepatology]

    Full ArticleGraphical Abstract
    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell Atlas of Human Liver Development Reveals Pathways Directing Hepatic Cell Fates

    Using transcriptomic analyses, researchers described the developmental trajectories of different cell types that make up the human liver at single-cell resolution.
    [Nature Cell Biology]

    Abstract

    Differential Expression of Hepatic Cancer Stemness and Hypoxia Markers in Residual Cancer After Locoregional Therapies for Hepatocellular Carcinoma

    Scientists investigated the differential expression of hepatic cancer stem cells and hypoxia in residual HCC after transarterial chemoembolization in comparison to transarterial radioembolization.
    [Hepatology Communications]

    Full Article

    Knockdown of Hepatocyte Perilipin-3 Mitigates Hepatic Steatosis and Steatohepatitis Caused by Hepatocyte CGI-58 Deletion in Mice

    Investigators tested whether the deletion of a major lipid droplet protein alleviated fatty liver pathogenesis caused by alpha/beta hydrolase domain containing 5 deficiency in hepatocytes.
    [Journal of Molecular Biology]

    Abstract

    TIPE1 Promotes Liver Regeneration by Enhancing Ros-FoxO1 Axis Mediated Autophagy

    Hepatic tumor necrosis factor alpha-induced protein 8-like (Tipe1) deficiency decreased the level of reactive oxygen species in hepatocytes, which led to the inhibition of FoxO1 acetylation and LC3I to LC3II conversion, and p62 accumulation.
    [FEBS Journal]

    Abstract

    A New Triazolothiadiazine Derivative Inhibits Stemness and Induces Cell Death in HCC by Oxidative Stress Dependent JNK Pathway Activation

    The authors investigated the cellular bioactivities of a series of triazolothiadiazine derivatives on HCC, which have been previously reported as potent analgesic/anti-inflammatory compounds.
    [Scientific Reports]

    Full Article
    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    REVIEWS

    Mitochondrial Fragmentation in Liver Cancer: Emerging Player and Promising Therapeutic Opportunities

    Scientists describe the mechanisms by which mitochondrial fragmentation (MF) contributes to HCC development, discuss potential therapeutic approaches, and the possibility that MF modulation has a synergistic effect with immunotherapy.
    [Cancer Letters]

    Abstract

    Liver Organoids: An In Vitro 3D Model for Liver Cancer Study

    The authors summarize the categories and development of liver organoids, and focus on the functions of culture medium components and applications of organoids for hepatitis B virus infection and associated liver cancer studies.
    [Cell & Bioscience]

    Full Article

    INDUSTRY AND POLICY NEWS

    FDA Grants GENFIT’s GNS561 Orphan Drug Designation for the Treatment of Cholangiocarcinoma

    GENFIT announced that the US FDA has granted orphan drug designation to GNS5611, a novel clinical-stage autophagy/PPT1 inhibitor, for the treatment of cholangiocarcinoma.
    [GENFIT]

    Press Release

    FEATURED EVENT

    EASL Liver Cancer Summit 2023

    April 20 – 22
    Estoril, Portugal

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Odette Cancer Research Program

    Sunnybrook Research Institute – Toronto, Ontario, Canada

    Postdoctoral Fellow – Human Liver Preservation and Regeneration

    University of California San Francisco – San Francisco, California, United States

    Senior Research Project Manager – NASH, Fibrosis, and Cirrhosis

    GENFIT – Lille, France

    Research Assistant/Associate – Mechanistic Drivers of Progression of NAFLD

    Newcastle University – Newcastle Upon Tyne, England, United Kingdom

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    > See All Jobs

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