Hepatic Cell News Volume 6.35 | Sep 23 2022

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    Laurisa Dohm
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    2022-09-23 | HCN 6.35


    Hepatic Cell News by STEMCELL Technologies
    Vol. 6.35 – 23 September, 2022
    TOP STORY

    Interleukin-33 Facilitates Liver Regeneration through Serotonin-Involved Gut-Liver Axis

    The authors investigated the role of interleukin-33 in liver regeneration after partial hepatectomy, to elucidate its underlying mechanisms.
    [Hepatology]

    Abstract
    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Melanoma Differentiation Associated Gene-9/Syndecan Binding Protein (MDA-9/SDCBP) Promotes Hepatocellular Carcinoma

    To unravel the function of MDA-9 in HCC, scientists generated and characterized a transgenic mouse with hepatocyte-specific overexpression of MDA-9.
    [Hepatology]

    Abstract

    MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling To Facilitate Metastasis in Hepatocellular Carcinoma

    Researchers investigated whether RNA binding proteins (RBPs) were important regulators of HCC metastasis.The RBP MEX3C was found to be significantly upregulated in highly metastatic HCC and correlated with poor prognosis in HCC.
    [Cancer Research]

    Abstract

    NcRNAs-Mediated High Expression of TICRR Promotes Tumor Cell Proliferation and Migration and Is Correlated With Poor Prognosis and Tumor Immune Infiltration of Hepatocellular Carcinoma

    Scientists demonstrated through a series of experiments that TICRR facilitated the proliferation and metastasis of liver cancer cells in vitro.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Preclinical Investigation of Artesunate as a Therapeutic Agent for Hepatocellular Carcinoma via Impairment of Glucosylceramidase-Mediated Autophagic Degradation

    Experiments revealed an association between autophagic activity and glucosylceramidase expression in clinical HCC samples, tumor tissues from a rat model of inflammation-induced HCC, an orthotopic mouse model, and human HCC cell lines.
    [Experimental and Molecular Medicine]

    Full Article

    MiR204 Potentially Promotes Non-Alcoholic Fatty Liver Disease by Inhibition of cpt1a in Mouse Hepatocytes

    The expression of miR204 was increased in mice with isocitrate dehydrogenase deficiency, which regulated carnitine palmitoyltransferase 1a (cpt1a) synthesis, inhibiting fatty acid β-oxidation.
    [Communications Biology]

    Full Article

    View tips on how to organize your lab bench space.
    REVIEWS

    Emerging Role of Carboxylesterases in Nonalcoholic Fatty Liver Disease

    The authors provide an overview of the relationship between carboxylesterases (CESs) and non-alcoholic fatty liver disease (NAFLD), and discuss the role and potential value of CESs in the treatment and prevention of NAFLD.
    [Biochemical Pharmacology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Inside the New Institute Looking at Early Cancer

    The Institute will see as many as 120 scientists from a broad spectrum of disciplines across the University – working together under one roof to understand the fundamental biology of how cancer develops and how it evolves, and applying that knowledge to pioneer new methods.
    [University of Cambridge]

    Press Release

    FEATURED EVENT

    Cell Symposia: Multifaceted Mitochondria

    November 6 – 8, 2022
    Seville, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellows – Molecular Metabolism

    University of Gothenburg – Gothenburg, Sweden

    Research Associate – Autoimmune Genomics

    Michigan State University – East Lansing, Michigan, United States

    Senior Research Project Manager – NASH, Fibrosis, and Cirrhosis

    GENFIT – Lille, France

    Research Assistant – Odette Cancer Research Program

    Sunnybrook Research Institute – Toronto, Ontario, Canada

    Postdoctoral Fellow – Human Liver Preservation and Regeneration

    University of California San Francisco – San Francisco, California, United States

    > See All Jobs

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