 | | Vol. 6.36 – 7 October, 2022 |
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| Researchers found that hepatotoxin-damaged and fibrotic livers gave rise to liver sinusoidal endothelial cells (LSECs)-iGap formation, which was positively correlated with increased numbers of metastatic liver foci after intrasplenic injection of Hepa1-6 cells.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors utilized patient samples and in vitro cell culture models including induced pluripotent stem cells, hepatocytes-like cells, immortalized cell lines, and primary human hepatocytes. Protein/mRNA expression were measured following treatment with poly(I:C), IFN-alpha (IFNα) and Hepatitis C virus infection.
[JHEP Reports] |
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| Investigators identified a hepatic endoplasmic reticulum (ER) stress-induced activating transcription factor 4 (ATF4)-cold-inducible RNA-binding protein (CIRP)-angiopoietin-related protein3 (ANGPTL3) cascade critical for the regulation of adipose browning.
[Cell Reports] |
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| Scientists found that HCC tissues had a higher 5-methylcytosine (m5C) methylation level than the adjacent normal tissues. Transcriptome analysis revealed that a major function of the hypermethylated genes participated in the phosphokinase signaling pathways, such as the Ras and PI3K-Akt pathways.
[Genomics Proteomics & Bioinformatics] |
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| Researchers found that the SEL1L-HRD1 complex of endoplasmic reticulum (ER)-associated degradation suppressed hepatocyte proliferation and tumorigenesis in mice. Hepatocyte-specific deletion of Sel1L or Hrd1 predisposed mice to diet/chemical-induced tumors.
[iScience] |
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| Investigators compared the transcriptome response of liver and quadriceps from mice on NASA Rodent Research 1, after 37 days exposure to spaceflight using GSEA, ORA, and Sparse Partial Least Square-Differential Analysis.
[iScience] |
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| The authors evaluated the cancer preventive efficacy of TAK-242, an inhibitor of toll-like receptor 4, in a mouse model of HCC occurring in the context of non-alcoholic steatohepatitis (NASH).
[Cancer Prevention Research] |
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| Hub gene expression levels, as well as those of their upstream lncRNAs and miRNAs and associated survival analyses, were conducted using appropriate bioinformatics databases. Predicted target relationships were used to establish putative ceRNA networks for Hepatitis C virus-related HCC.
[Heliyon] |
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| The authors review how inflammatory responses affect metabolic processes such as energy homeostasis and insulin signaling, focusing mainly on the role of cell death in the adipose tissue as a key player in metabolic inflammation.
[Cell Death & Differentiation] |
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| A team of multidisciplinary scientists has been awarded the prestigious National Research Foundation (NRF) Singapore grant to uncover the fundamental mechanisms of liver disease progression from fatty liver disease to fibrosis/cirrhosis, and eventually, liver cancer.
[Agency for Science, Technology and Research (A*STAR)] |
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| November 7 – 9, 2022
Singapore, Singapore |
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| | Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States |
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| | Garvan Institute of Medical Research – Sydney, Australia |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Michigan State University – East Lansing, Michigan, United States |
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