 | | Vol. 6.38 – 21 October, 2022 |
| | | Hepatocyte-specific knockdown of Vps37a caused an accumulation of glucagon receptor in endosomes, resulting in overactivation of the cAMP/PKA/p-Creb signaling pathway to gluconeogenesis without affecting β-oxidation.
[Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Mechanistically, glutamine synthetase ablation exacerbated hyperammonemia and facilitated the production of glutamate-derived non-essential amino acids , which subsequently stimulated mTORC1.
[Journal of Clinical Investigation] |
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| Bioinformatics analysis and immunohistochemical results showed that NAD(P)H quinone oxidoreductase-1 (NQO1) was highly expressed in HCC tissues. Overexpression of NQO1 promoted the cell proliferation, epithelial-to-mesenchymal transition process, and angiogenesis of HCC cells.
[Oncogene] |
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| Microarray analysis identified the differentially expressed vascular endothelial zinc finger 1 (VEZF1) in HCC, and its raised expression was validated in HCC clinical samples. Artificial modulation of VEZF1 (knockdown and overexpression) was conducted to explore its role in HCC progression both in vitro and in vivo.
[Oncogene] |
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| The radioresistant role of nuclear protein 1 (NUPR1) was determined by colony formation assay, comet assay in vitro, and xenograft tumor models in vivo.
[BMC Medicine] |
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| Scientists showed that mesenchymal stem cells restored the impaired autophagic flux and alleviated liver injuries in acute-on-chronic liver failure mice, but these effects were abolished when autophago-lysosomal maturation was inhibited by leupeptin.
[Cell Death & Disease] |
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| The authors discuss the global epidemiology, projections, and risk factors for alcohol-associated cirrhosis and HCC.
[Nature Reviews Gastroenterology & Hepatology] |
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| Scientists review the available literature on hepatic toll-like receptor (TLR) expression and signaling; crosstalk between gut microbiota and hepatic TLRs, and the contribution of TLRs to the pathogenesis of metabolic (dysfunction)-associated fatty liver disease.
[Pharmacological Research] |
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| Eureka Therapeutics, Inc. announced that the FDA has granted Orphan Drug Designation to ET140203 for the treatment of hepatoblastoma, a rare childhood tumor in the liver that typically occurs in children under the age of 5.
[Eureka Therapeutics, Inc.] |
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| March 26 – 31, 2023
Ventura, California, United States |
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| | The Roger Williams Institute of Hepatology – London, United Kingdom |
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| | Institute of Hepatology, Foundation for Liver Research – London, England, United Kingdom |
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| | NCI – Bethesda, Maryland, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | STEMCELL Technologies – Vancouver, British Columbia, Canada |
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