Hepatic Cell News Volume 6.39 | Oct 28 2022

October 28, 2022

2022-10-28 | HCN 6.39

Hepatic Cell News by STEMCELL Technologies

Vol. 6.39 – 28 October, 2022

TOP STORY

Hepatic Thyroid Hormone Signaling Modulates Glucose Homeostasis through the Regulation of GLP-1 Production via Bile Acid-Mediated FXR Antagonism

3,5,3’-triiodo-L-thyronine suppressed Cyp8b1 expression, resulting in increased the levels of Farnesoid X receptor (FXR)-antagonistic bile acids, thereby potentiating glucagon-like peptide-1 (GLP-1) production and insulin secretion by repressing intestinal FXR signaling.
[Nature Communications]

Full Article

Easy250 EasySep Magnet for rapid immune cell isolation from large-volume samples.

PUBLICATIONSRanked by the impact factor of the journal

Generation of Functionally Competent Hepatic Stellate Cells From Human Stem Cells to Model Liver Fibrosis In Vitro

Scientists established robust endoderm- and mesoderm-sourced quiescent-like induced hepatic stellate cells derived from human pluripotent stem cells.
[Stem Cell Reports]

Full Article Graphical Abstract

FBXO31 Sentisizes CSC-Like Cells to Cisplatin by Promoting Ferroptosis and Facilitating Proteasomal Degradation of GPX4 in CCA

The biological functions of FBXO31 were confirmed in vivo and in vitro. Sphere formation and flow cytometry were used to identify the stem cell properties of cholangiocarcinoma (CCA).
[Liver International]

Abstract

Downregulation of TUSC3 Promotes EMT and Hepatocellular Carcinoma Progression through LIPC/AKT Axis

Loss-of-function and gain-of-function were applied to detect the function of Tumor Suppressor Candidate 3 (TUSC3) and lipase C hepatic type (LIPC) in vivo and in vitro.
[Journal of Translational Medicine]

Full Article

The Interplay of Transcriptional Coregulator NUPR1 with SREBP1 Promotes Hepatocellular Carcinoma Progression via Upregulation of Lipogenesis

CCK-8, EdU and colony formation assays were performed to explore the effect of nuclear protein 1 (NUPR1) on the proliferation of HCC cells.
[Cell Death Discovery]

Full Article

Crosstalk Between HSF1 and STAT3 Mediated by IL-8 Autocrine Signaling Maintains the Cancer Stem Cell Phenotype in Liver Cancer

Researchers established two liver cancer stem cells (LCSC) lines, HepG2-R and HuH-7-R. Constitutive activation of HSF1 was observed in these LCSCs.
[Journal of Gastroenterology and Hepatology]

Full Article

REVIEWS

Mechanisms of Pruritus in Cholestasis: Understanding and Treating the Itch

Investigators provide an update on the latest insights into the molecular pathogenesis of and novel therapeutic approaches for cholestasis-associated itch.
[Nature Reviews Gastroenterology & Hepatology]

Full Article

Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control

The authors focus on the main resources of mesenchymal stem cells (MSCs), underlying therapeutic mechanisms, clinical applications, and efforts made to improve MSC-based cell therapy efficiency.
[Stem Cells International]

Full Article

INDUSTRY AND POLICY NEWS

Imjudo (Tremelimumab) in Combination with Imfinzi Approved in the US for Patients with Unresectable Liver Cancer

AstraZeneca’s Imjudo in combination with Imfinzi has been approved in the US for the treatment of adult patients with unresectable HCC.
[AstraZeneca Inc.]

Press Release

FEATURED EVENT

Hepatic Cell News Volume 6.39 | Oct 28 2022

Hepatic Thyroid Hormone Signaling Modulates Glucose Homeostasis through the Regulation of GLP-1 Production via Bile Acid-Mediated FXR Antagonism

Generation of Functionally Competent Hepatic Stellate Cells From Human Stem Cells to Model Liver Fibrosis In Vitro

FBXO31 Sentisizes CSC-Like Cells to Cisplatin by Promoting Ferroptosis and Facilitating Proteasomal Degradation of GPX4 in CCA

Downregulation of TUSC3 Promotes EMT and Hepatocellular Carcinoma Progression through LIPC/AKT Axis

The Interplay of Transcriptional Coregulator NUPR1 with SREBP1 Promotes Hepatocellular Carcinoma Progression via Upregulation of Lipogenesis

Crosstalk Between HSF1 and STAT3 Mediated by IL-8 Autocrine Signaling Maintains the Cancer Stem Cell Phenotype in Liver Cancer

Mechanisms of Pruritus in Cholestasis: Understanding and Treating the Itch

Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control

Imjudo (Tremelimumab) in Combination with Imfinzi Approved in the US for Patients with Unresectable Liver Cancer

Emerging Cellular Therapies at the Forefront of Cancer Immunotherapy

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PhD Candidate – Spatial and Single Cell Transcriptomics

Senior Scientist – Receptor Pharmacology and Cell Signaling

Postdoctoral Fellow – Micro-Sampling and Biomarkers

Science Communications Manager – Liver Research

Postdoctoral Position – Advanced Tumoroid Biology

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