Hepatic Cell news Volume 6.40 | Nov 4 2022

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    2022-11-04 | HCN 6.40


    Hepatic Cell News by STEMCELL Technologies
    Vol. 6.40 – 4 November, 2022
    TOP STORY

    Non-Canonical Phosphoglycerate Dehydrogenase Activity Promotes Liver Cancer Growth via Mitochondrial Translation and Respiratory Metabolism

    Researchers showed that phosphoglycerate dehydrogenase localized to the inner mitochondrial membrane and promoted the translation of mitochondrial DNA-encoded proteins in liver cancer cells.
    [EMBO Journal]

    AbstractGraphical Abstract
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Disrupting Metformin Adaptation of Liver Cancer Cells by Targeting the TOMM34/ATP5B Axis

    Investigators found that long-term metformin exposure led to metabolic adaptation of HCC cells, which was characterized by an obvious epithelial-mesenchymal transition phenotype and compensatory elevation of oxidative phosphorylation.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Ablation of Sphingosine Kinase 2 Suppresses Fatty Liver-Associated Hepatocellular Carcinoma via Downregulation of Ceramide Transfer Protein

    Scientists reported that sphingosine kinase 2, a key sphingolipid metabolic enzyme, played a critical role in non-alcoholic fatty liver disease-associated HCC.
    [Oncogenesis]

    Full Article

    DNASE1L3 Inhibits Hepatocellular Carcinoma by Delaying Cell Cycle Progression through CDK2

    Investigators found that DNASE1L3 was significantly downregulated and served as a favorable prognostic factor in HCC.
    [Cellular Oncology]

    Abstract

    Metformin Alleviates HFD-Induced Oxidative Stress in Hepatocyte via Activating SIRT6/PGC-1α/ENDOG Signaling

    By taking advantage of mouse model of high-fat-diet-induced (HFD) obesity and primary mouse hepatocytes as well as human hepatocyte L02 cell line, scientists investigated the involvement of SIRTs during the application of metformin for the therapy of type 2 diabetes.
    [Clinical Science]

    Abstract

    Targeted Activation of HNF4α/HGF1/FOXA2 Reverses Hepatic Fibrosis via Exosome-Mediated Delivery of CRISPR/dCas9-SAM System

    The authors constructed a modified-exosome delivery system targeting hepatic stellate cells (HSCs), and constructed the CRISPR/dCas9-SAM system inducing HSCs convert into hepatocyte-like cells in vitro and in vivo.
    [Nanomedicine]

    AbstractGraphical Abstract
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    REVIEWS

    Liver Iron Loading in Alcohol-Associated Liver Disease

    Scientists review the cellular mechanisms underlying alcohol-induced liver iron loading and discuss how excess iron in patients with alcohol-associated liver disease can promote liver fibrosis and aggravate disease pathology.
    [American Journal of Pathology]

    Full Article
    INDUSTRY AND POLICY NEWS

    FDA Acceptance of Auransa’s IND Application for AU409 for Treatment of Patients with Hepatocellular Carcinoma

    Auransa, Inc. announced that the US FDA has accepted its Investigational New Drug (IND) application for AU409, a novel, orally active agent showing anticancer activity in preclinical studies of HCC.
    [Auransa, Inc. (EIN Presswire)]

    Press Release

    Omega Therapeutics Receives Orphan Drug Designation for OTX-2002 for the Treatment of Hepatocellular Carcinoma

    Omega Therapeutics, Inc. announced that the US FDA has granted Orphan Drug Designation for OTX-2002, the company’s first-in-class epigenomic controller engineered to downregulate c-Myc, for the treatment of HCC.
    [Omega Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Research Associate – Liver R&D

    Aspect Biosystems – Vancouver, British Columbia, Canada

    PhD Candidate – Spatial and Single Cell Transcriptomics

    Helmholtz Munich – Neuherberg, Germany

    Senior Scientist – Receptor Pharmacology and Cell Signaling

    Novo Nordisk – Seattle, Washington, United States

    Postdoctoral Fellow – Micro-Sampling and Biomarkers

    AstraZeneca – Gothenburg, Sweden

    Science Communications Manager – Liver Research

    The Roger Williams Institute of Hepatology – London, England, United Kingdom

    > See All Jobs

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