 | | Vol. 6.41 – 18 November, 2022 |
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| Modest overexpression of SIRT4 protected the liver from fibrosis by inhibiting the transformation of glutamate to 2-ketoglutaric acid in the tricarboxylic acid cycle, thereby reducing the proliferative activity of hepatic stellate cells.
[Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Cell-based experiments showed that elevated levels of GALNT14 promoted HCC growth, migration, and resistance to anticancer drugs.
[Cell Death & Disease] |
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| Researchers investigated the interplay among neuropilin-1, autophagy, and hypoxia in the development of lenvatinib resistance in HCC cell lines.
[Acta Pharmacologica Sinica] |
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| Human liver samples, Bgn–/0 mice and a human LX-2 hepatic stellate cells model were applied for the study of experimental fibrosis.
[Liver International] |
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| Scientists examined the potential role of SGOL2 in cancers, especially in HCC. Immunohistochemistry, immunofluorescence, western blot, o-immunoprecipitation technique, and bioinformatic analysis were utilized to assess the role of SGOL2 in HCC development process.
[Biomarker Research] |
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| In vitro and in vivo gain- and loss-of-function experiments showed that LINC01468 promoted the proliferation of HCC cells through lipogenesis.
[Cell Death Discovery] |
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| Investigators performed RNA sequencing of liver biopsies from ten HCC, ten hepatitis C virus-associated HCC, and four normal livers to identify dysregulated lncRNAs in HCC.
[Scientific Reports] |
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| To clarify the effects and mechanisms of gemigliptin, the authors conducted various experiments in LX-2 cells, which were activated by succinate and exhibited elevated expression of α-smooth muscle actin, collagen type 1, and pro-inflammatory cytokines and increased cell proliferation.
[Endocrinology and Metabolism] |
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| Among a series of novel small-molecule compounds, a potential anti-fibrosis drug compd.1 was founded to be able to dose-dependently down-regulate ACTA2 and CTGF mRNA levels in human hepatic stellate cells treated with TGF-β.
[Bioorganic & Medicinal Chemistry] |
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| Investigators summarize the latest clinical advances in the treatment of advanced HCC and discuss future perspectives that might inform the development of more effective therapeutics for advanced HCC.
[Nature Reviews Gastroenterology & Hepatology] |
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| The authors review the mechanisms of hepatic regeneration and their potential to influence HCC development.
[Trends in Cancer] |
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| Scientists highlight the importance of protein phosphatases in HCC development and in the regulation of the cellular components in the liver microenvironment and to show their significance as therapeutic targets.
[Experimental and Molecular Medicine] |
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| Escient Pharmaceuticals announced the initiation of a Phase II clinical study of EP547 in subjects with cholestatic pruritus. EP547 is a highly selective antagonist of MRGPRX4, a cell surface receptor expressed on sensory neurons that is activated by bile acids, bilirubin and other heme metabolite.
[Escient Pharmaceuticals] |
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| The Hepatitis B Foundation, a global nonprofit organization, today announced that Stephan Urban, PhD, distinguished professor and globally recognized virologist, has been chosen to receive its 2023 Baruch S. Blumberg Prize.
[Hepatitis B Foundation] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | University of Bristol – Bristol, United Kingdom |
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| | Imperial College London – London, England, United Kingdom |
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| | Helmholtz Munich – Neuherberg, Germany |
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| | Novo Nordisk – Seattle, Washington, United States |
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