 | | Vol. 6.42 – 25 November, 2022 |
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| The authors studied two commonly used models for organ growth control, the Drosophila eye and the mouse liver, in which they examined the effects of loss of Hippo signaling output on growth and its pattern of activity during normal development.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Unexpectedly, investigators found that acetyl-CoA levels were decreased in HCC due to transcriptional downregulation of all six acetyl-CoA biosynthesis pathways.
[Molecular Cell] |
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| Scientists demonstrated that liver-specific loss of Arid2 induced hepatic steatosis and this progression could be exacerbated by a high-fat diet.
[Cell Death & Differentiation] |
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| Researchers demonstrated that branched-chain amino acid (BCAA) catabolism was activated in liver cancer cells without glutamine, leading to BCAA-derived carbon and nitrogen flow toward nucleotide synthesis.
[Cell Reports] |
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| Mechanistic assays such as luciferase reporter analysis, and chromatin immunoprecipitation revealed the molecular mechanism of the Myc/circMcph1/miR-370-3p/Irak2 axis in hepatic fibrosis.
[Life Sciences] |
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| TINCR was found to be highly expressed in HCC tissues and liver cancer stem cells (LCSCs). In vitro and in vivo assays for the first time showed that TINCR was required for LCSC self-renewal and tumorigenesis.
[Cell Death & Disease] |
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| Overexpression and silencing assays confirmed that Mir122hg played a protective role in acute injury by promoting hepatocyte proliferation in vivo and in vitro.
[Experimental and Molecular Medicine] |
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| Hepatocytes with HBV surface antigen expression exhibited increased glucose production and expression of gluconeogenic genes glucose-6-phosphatase and phosphoenolpyruvate carboxykinase in response to glucagon stimulation.
[Journal of Virology] |
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| In vitro and in vivo experiments were conducted to detect the effect of disc large associated protein 4 (DLGAP4) expression on the proliferation, migration and metastasis of HCC cells.
[Scientific Reports] |
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| The perisinusoidal space serves as a critical hub for activating hepatic stellate cells and their interactions with other cell types, which causes a variety of liver diseases such as hepatic inflammation, fibrosis, cirrhosis, and therefore the authors review intercellular communication in this space.
[Journal of Cellular Physiology] |
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| Michael Nathanson, MD, PhD, Gladys Crofoot Professor of Medicine (Digestive Diseases) and professor of cell biology, received the 2022 Distinguished Service Award from the American Association for the Study of Liver Disease (AASLD) during its annual meeting.
[Yale School of Medicine] |
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| March 6 – 8, 2023
Paris, France |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | Cleveland Clinic, Lerner Research Institute – Cleveland, Ohio, United States |
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| | Indiana University School of Medicine – Bloomington, Indiana, United States |
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| | International Agency for Research on Cancer, WHO – Lyon, France |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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