 | | Vol. 6.43 – 2 December, 2022 |
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| Investigators discovered IL6, combined with epidermal growth facto and hepatocyte growth factor, promoted long-term expansion of primary mouse hepatocytes in vitro in simple 2D culture, by converting hepatocytes into induced hepatic progenitor cells.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Bile duct ligation and carbon tetrachloride challenge were used to assess anti-fibrotic effects of GL-V9 in vivo. Mouse primary hepatic stellate cells and human HSC line LX2 also served as an in vitro liver fibrosis model.
[British Journal of Pharmacology] |
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| Investigators found that pharmacological and genetic inhibition of 111β-hydroxysteroid dehydrogenase type 1 resulted in reprogramming of hepatic stellate cell activation via inhibition of p-SMAD3, α-SMA, Snail, and Col1A1 in a fibrotic environment and in multicellular hepatic spheroids.
[Cell Death & Disease] |
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| Scientists analyzed the relationship between A20 and Rac1 activation, as well as the activity of Akt and mTORC2, two signaling components upstream of Rac1, using gain and loss of function experiments.
[Cancer Gene Therapy] |
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| The authors presented the proteome of nine commonly used HCC cell lines covering 9,208 protein groups, and the HCC spectral library containing 253,921 precursors, 168,811 peptides and 10,098 protein groups.
[Scientific Data] |
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| The inhibitory effects of the identified miRNAs in HepG2 and Huh7 cells were verified by real-time PCR. The MTT assay was utilized to evaluate cell cytotoxicity effects of miRNAs.
[Scientific Reports] |
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| Investigators developed a simple dialysis-based medium conditioning that fully utilized growth factors accumulation to improve hepatic differentiation of human induced pluripotent stem cells at a high cell density.
[Scientific Reports] |
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| Cell growth was tested by CCK8 assay, and Transwell assays were performed to assess cancer cell migration and invasion. The cAMP/ERK/CREB signaling pathway was evaluated by Western blot analysis and ELISA.
[BMC Cancer] |
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| Researchers appraised the clinico-pathological significance of acid phosphatase type 6 in HCC via organizing expression profiles from globally multi-center microarrays and RNA-seq datasets. The molecular basis of ACP6 in HCC was explored through multidimensional analysis.
[BMC Cancer] |
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| One of the most common causes of cancer chemoresistance and relapse is the presence and percentage of cancer stem cells (CSCs), among them CD47+ CSCs.
[International Immunopharmacology] |
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| Investigators provide an updated summary on the current pathogenesis and mechanism of liver injury in the setting of SARS-CoV-2 infection, the association between health outcomes and SARS-CoV-2 infection in patients with chronic liver disease.
[Gut and Liver] |
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| Shanghai Junshi Biosciences Co., Ltd announced that the company has submitted a marketing authorization application to the United Kingdom’s Medicines and Healthcare products Regulatory Agency for toripalimab
[Shanghai Junshi Biosciences Co., Ltd (GlobeNewswire, Inc.)] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | The Ottawa Hospital – Ottawa, Ontario, Canada |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | Cleveland Clinic, Lerner Research Institute – Cleveland, Ohio, United States |
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| | Norwegian University of Science and Technology – Trondheim, Norway |
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| | International Agency for Research on Cancer, WHO – Lyon, France |
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