 | | Vol. 6.45 – 9 December, 2022 |
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| Plasmodium falciparum (Pf) sporozoites invaded human hepatocytes in culture and developed to mature liver-stage schizonts expressing Pf merozoite surface protein in numbers comparable to those manufactured in mosquitoes.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers loaded liquid chromatography column housings with induced pluripotent stem cell derived liver organoids and coupled the “organ-in-a-column” units on-line with liquid chromatography-mass spectrometry.
[Analytical Chemistry] |
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| Coiled-coil-helix-coiled-coil-helix domain-containing (CHCHD2)-overexpressing hepatocytes activated hepatic stellate cells by upregulating osteopontin levels, a downstream mediator of Notch signals.
[JCI Insight] |
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| The authors investigated the expression pattern of aldolase A (ALDOA) in hepatocellular carcinoma and its biological role in tumour progression. Bioinformatics analysis, western blot and RT-qPCR were performed to detect the relative expression of ALDOA in HCC tissues and cell lines.
[Scientific Reports] |
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| The interaction between CCAT2 and miR-34a-5p was checked by dual luciferase assay. The effects of CCAT2 and miR-34a-5p on cell proliferation and apoptosis were verified by MTT assay, colony formation assay, and flow cytometry assay.
[Scientific Reports] |
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| The transwell, wound-healing assay was employed to determine the effects of KIN17 on migration and invasion of HCC cells in vitro.
[Molecular Carcinogenesis] |
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| Researchers investigated the function of circFUT8 in HCC and its interaction with exosomes, M1 macrophages, and m6A.
[Cellular & Molecular Biology Letters] |
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| Exosomes were isolated by ultracentrifugation, and characterized by transmission electron microscopy, nanoflow cytometry, and western blot assay. The internalization of exosomes by HCC cells was observed under a fluorescence microscope.
[BMC Gastroenterology] |
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| The authors aimed to confirm Klotho expression in normal canine liver tissues using western blotting and immunohistochemistry, and whether the expression differed in non-neoplastic liver disease and HCC.
[Veterinary and Comparative Oncology] |
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| 870 Liver-Chips were analyzed to determine their ability to predict drug-induced liver injury caused by small molecules identified as benchmarks by the Innovation and Quality consortium, who had published guidelines defining criteria for qualifying preclinical models.
[Communications Medicine] |
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| Scientists summarize research developments on the mechanism of action and clinical evidence of metformin and discusses its therapeutic potential and clinical safety.
[Molecular Biomedicine] |
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| Horizon Therapeutics plc announced the first subject had been dosed in a Phase I randomized, placebo-controlled trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of its development-stage medicine HZN-457, previously known as ARO-XDH.
[Horizon Therapeutics plc] |
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| Akero Therapeutics, Inc. announced that efruxifermin received a Breakthrough Therapy Designation from the FDA for the treatment of nonalcoholic steatohepatitis.
[Akero Therapeutics, Inc.] |
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| March 19 – 21, 2023
Sitges, Spain |
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| | The Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany |
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| | The Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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