 | | Vol. 6.46 – 16 December, 2022 |
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| Tumoral Prdm1 overexpression upregulated PD-L1 levels, dampening anti-tumor immunity in vivo, and neutralized the anti-tumor efficacy of Prdm1 overexpression in immune-competent mouse models.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators described the derivation of syngeneic induced pluripotent stem cells (iPSCs) engineered to determine the effects of Z alpha-1 antitrypsin heterozygosity in iPSC-hepatocytes.
[Cell Reports] |
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| Scientists dissected the impact of activated mTORC1 on the cell-cell interaction of Kupffer cells (KCs) and hepatocyte in immune-mediated hepatitis. In the liver from patients with AIH and mice administrated with Con-A, mTORC1 was activated in both KCs and hepatocytes.
[Cell Death & Disease] |
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| Mouse serum extracellular vesicles were isolated and identified using nanoparticle tracking analysis and transmission electron microscopy. Mouse hepatocytes and primary hepatic stellate cells were used to investigate the cell-to-cell crosstalk.
[Journal of Cell Communication and Signaling] |
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| Researchers established reliable in vitro non-alcoholic steatohepatitis models using different mixtures of variable ratios and concentrations of oleic acid and palmitic acid combinations using HepG2 cell lines.
[Molecular and Cellular Biochemistry] |
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| Hepatic architecture, liver size, endothelial differentiation, and angiocrine functions were unaltered in Lyve-1-KO. Hyaluronan plasma levels were significantly increased in Lyve-1-KO.
[Cancer Cell International] |
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| Scientists evaluated the protection and the mechanisms of action of citrus flavanone metabolites, hesperetin 7-glucuronide and 3-(4′-hydroxyphenyl) propanoic acid, on pancreatic β-cell function under oxidative stress induced by cholesterol using the global proteomics approach.
[Food & Function] |
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| In the presence of palmitic acid, reactive oxygen species production was increased at three hours, followed by enhancement of expression of p-PERK, ATF4, p-eIF2α, CHOP, and TXNIP and p-p62 and LC3II/LC3I ratio, in both primary hepatocytes and AML12 cells.
[Food and Chemical Toxicology] |
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| Inflammation is an important driver in the pathogenesis of non-alcoholic steatohepatitis, and the mechanisms underlying inflammation in non-alcoholic fatty liver disease represent possible therapeutic targets.
[Journal of Endocrinology] |
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| Recovery of the native liver depends on activation of apoptotic and regenerative pathways, including the integrated stress response (ISR; e.g., PERK), p53, and HNF4α.
[Trends in Molecular Medicine] |
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| The blockage of spleen tyrosine kinase (SYK) activity using small molecule modulators is considered as a significant therapeutic strategy against liver diseases, and both hepatic SYK and non-hepatic SYK could become highly promising therapeutic targets.
[Heliyon] |
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| Genflow has announced that it has filed a new patent application with the US Patent and Trademark Office that relates to variants of Sirtuin-6, and the gene variant’s therapeutic uses for the treatment of two disorders involving the liver: NAFLD, and non-alcoholic steatohepatitis.
[Genflow (First Longevity Ltd)] |
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| The University of Kentucky Markey Cancer Center has received renewed funding from the American Cancer Society to support a long-standing faculty research program.
[University of Kentucky] |
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| February 19 – 22, 2023
Banff, Alberta, Canada |
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| | Rutgers Biomedical and Health Sciences – Newark, New Jersey, United States |
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| | Mammoth Biosciences, Inc. – Brisbane, California, United States |
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| | The Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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