 | | Vol. 7.00 – 6 January, 2023 |
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| To identify antifibrotic drug targets, researchers integrated progressive transcriptomic and morphological responses that accompanied hepatic stellate cell activation in advanced disease using single-nucleus RNA sequencing.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed a global lactylome profiling on a prospectively collected hepatitis B virus-related HCC cohort. They revealed that lysine lactylation played an important role in regulating cellular metabolism and may contribute to HCC progression.
[Nature Metabolism] |
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| The authors suggested that the circadian clock regulators BMAL1 and CLOCK promoted HCC cell proliferation by controlling Wee1 and p21 levels, thereby preventing apoptosis and cell cycle arrest.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators generated krüpple-Like factor 14 (KLF14) overexpression and silencing liver cancer cells, and nude mouse xenograft models for the in vitro and in vivo study exploring the function of KLF14 in HCC.
[Journal Of Experimental & Clinical Cancer Research] |
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| Scientists identifed a population of “liver-type” innate lymphoid cells 1 with transcriptional, phenotypic, and functional features distinct from those of conventional and liver-resident natural killer cells.
[Cell Reports] |
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| Investigators showed that, in HCC, speckle-type POZ protein (SPOP) was highly O-GlcNAcylated by O-GlcNAc transferase at Ser96.
[Oncogene] |
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| Scientists designed a study to reveal the effect and underlying mechanism of Josephin-2, a relatively newly defined deubiquitinating enzyme, in HCC progression.
[Genes & Genomics] |
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| Researchers investigated the effect of a physiologically relevant, low concentration of cadmium on the regulation of liver cancer cell proliferation, steatosis, and fibrogenic/oncogenic signaling.
[Environmental Toxicology] |
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| Scientists showed that liver sinusoidal endothelial cell senescence-accelerated liver sinusoid capillarization and promoted steatosis by reprogramming liver endothelial zonation and inactivating pericentral endothelium-derived C-kit.
[Nature Aging] |
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| Investigators review and describe the different approaches for the development of liver models currently used in the field of tissue engineering.
[Biomaterials Science] |
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| The authors review the metabolic links between diet-induced changes in the gut and non-alcoholic steatohepatitis and discuss the therapeutic interventions for the treatment of obesity and liver metabolic diseases.
[iScience] |
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| Madrigal Pharmaceuticals, Inc. announced additional results from the pivotal Phase III MAESTRO-NASH biopsy clinical trial of resmetirom, a liver-directed selective thyroid hormone receptor agonist.
[Madrigal Pharmaceuticals, Inc.] |
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| January 24 – 26, 2023
Boston, Massachusetts, United States |
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| | Stanford Medicine – Stanford, California, United States |
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| | University of Vermont – Burlington, Vermont, United States |
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| | Columbia University – New York, New York, United States |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | UTHSC-Houston – Houston, Texas, United States |
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