Hepatic Cell News Volume 7.01 | Jan 13 2023

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    2023-01-13 | HCN 7.01


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.01 – 13 January, 2023
    TOP STORY

    An Autocrine Signaling Circuit in Hepatic Stellate Cells Underlies Advanced Fibrosis in Nonalcoholic Steatohepatitis

    To identify antifibrotic drug targets, scientists integrated progressive transcriptomic and morphological responses that accompany hepatic stellate cells activation in advanced disease using single-nucleus RNA sequencing and tissue clearing in a robust murine NASH model.
    [Science Translational Medicine]

    AbstractPress Release
    ON1153CC-CPA-Liver Organoid_160 x 600_728 x 90
    PUBLICATIONSRanked by the impact factor of the journal

    S100A10 Promotes HCC Development and Progression via Transfer in Extracellular Vesicles and Regulating Their Protein Cargos

    The functions and mechanisms of S100A10 and EV-S100A10 in HCC progression were investigated in vitro and in vivo. Neutralizing antibody to S100A10 was used to evaluate the significance of EV-S100A10.
    [Gut]

    Full Article

    Targeting Lin28 Axis Enhances Glypican-3-CAR T Cell Efficacy Against Hepatic Tumor Initiating Cell Population

    Results usingHCC patient samples showed a positive correlation between indoleamine 2,3-dioxygenase-1, a kynurenine producing enzyme with effects on tumor immune escape, and Lin28B.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Multivalent Lactobionic Acid and N-Acetylgalactosamine-Conjugated Peptide Nucleic Acids for Efficient In Vivo Targeting of Hepatocytes

    Scientists reported the synthesis, characterization, in vitro and in vivo study of di lactobionic acid and tris N-acetyl galactosamine conjugated peptide nucleic acids for liver-targeted delivery.
    [Advanced Healthcare Materials]

    Abstract

    Elimination of Cancer Cells in Co-Culture: Role of Different Nanocarriers in Regulation of CD47 and Calreticulin-Induced Phagocytosis

    The authors postulated that using a modified graphene oxide carrier to deliver small interfering RNA CD47 in acute myeloid leukemia, A549 lung, and HepG2 liver cancer cells in co-culture in vitro would silence CD47 and flag cancer cells for calreticulin-mediated phagocytosis.
    [Acs Applied Materials & Interfaces]

    Full ArticleGraphical Abstract

    Salvianolic Acid B Suppresses Hepatic Fibrosis by Inhibiting Ceramide Glucosyltransferase in Hepatic Stellate Cells

    Researchers investigated the role of UDP-glucose ceramide glucosyltransferase (UGCG) in the pathogenesis of hepatic fibrosis. They first found that UGCG was over-expressed in fibrotic livers and activated hepatic stellate cells.
    [Acta Pharmacologica Sinica]

    Abstract

    Mid-Line 1 Interacting Protein 1 Promotes Cancer Metastasis via FOS Like 1-Mediated Matrix Metalloproteinase 9 Signaling in HCC

    Using whole transcriptome sequencing of patients’ HCCs, investigators identified and validated Mid-line 1 interacting protein 1 as one of the most significantly upregulated genes in metastatic HCCs, suggesting its potential role in HCC metastasis.
    [Hepatology]

    Abstract

    Targeting VPS72 Inhibits ACTL6A/MYC Axis Activity in Hepatocellular Carcinoma Progression

    Scientists revealed the molecular mechanism of ACTL6A/VPS72/MYC in HCC, providing a theoretical basis and therapeutic target for this malignancy.
    [Hepatology]

    Abstract

    A Potent Ion Channel Blocker, Hydroquinidine, Exhibits Strong Anti-Cancer Activity on Colon, Pancreatic, and Hepatocellular Cancer Cells

    Hydroquinidine’s potential as an anti-neoplastic compound was examined using colony formation assay, wound healing assay, soft agar assay, and Annexin-V assay in the colon, pancreatic, and hepatocellular carcinomas.
    [Molecular Biology Reports]

    Abstract
    Easy250 EasySep Magnet for rapid immune cell isolation from large-volume samples.
    REVIEWS

    Checkpoint Inhibitor Hepatotoxicity: Pathogenesis and Management

    Based on the existing literature, scientists propose evolving management approaches to incorporate strategies to limit excess corticosteroid exposure, and address rare but important presentations of cholestatic hepatitis and fulminant liver failure.
    [Hepatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Pinnacle Completes Purchase of South Texas Research Institute with Focus on NASH

    Pinnacle Clinical Research, part of the LongueVue Capital portfolio, completed its acquisition of the South Texas Research Institute, which is known for its clinical research of nonalcoholic steatohepatitis (NASH).
    [Fierce Biotech]

    Press Release
    FEATURED EVENT

    Lund Stem Cell Center 20th Anniversary

    April 17 – 19, 2023
    Lund, Sweden

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    JOB OPPORTUNITIES

    Group Leader – Cell Biology

    Pompeu Fabra University – Barcelona, Spain

    Postdoctoral Research Fellow – Chronic Liver Disease

    Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

    Faculty Position – Academic Gastrointestinal/Liver Pathologist

    University of Vermont – Burlington, Vermont, United States

    Research Scientist – Cancer Molecular Imaging

    Stanford Medicine – Stanford, California, United States

    Associate Research Scientist – Stem Cells and Tissue Engineering

    Columbia University – New York, New York, United States

    > See All Jobs

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