Hepatic Cell News Volume 7.02 | Jan 20 2023

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    2023-01-20 | HCN 7.02


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.02 – 20 January, 2023
    TOP STORY

    Type 2 Diabetes Candidate Genes, including PAX5, Cause Impaired Insulin Secretion in Human Pancreatic Islets

    The authors found 395 differentially expressed genes in islets from individuals with type 2 diabetes, including novel and previously identified candidates.
    [Journal Of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract
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    The Role of Altered Lipid Composition and Distribution in Liver Fibrosis Revealed by Multimodal Nonlinear Optical Microscopy

    Researchers established a multimodal nonlinear optical microscopy to quantitatively map distribution of biomolecules in fibrotic livers.
    [Science Advances]

    Full Article

    TRIM15 Forms a Regulatory Loop with the AKT/FOXO1 Axis and LASP1 to Modulate the Sensitivity of HCC Cells to TKIs

    Scientists demonstrated that TRIM15 was abnormally upregulated in liver cancer cells after treated with tyrosine kinase inhibitors and that this upregulation of TRIM15 contributed to tyrosine kinase inhibitors (TKI) resistance in liver cancer cells.
    [Cell Death & Disease]

    Full Article

    In Vitro Generated Equine Hepatic-Like Progenitor Cells as a Novel Potent Cell Pool for Equine Metabolic Syndrome (EMS) Treatment

    The authors hypothesized that in vitro induction of Eq_ASCs hepatogenic differentiation would generate a specialized liver progenitor-like cell population exhibiting similar phenotypic characteristics and regenerative potential as native hepatic progenitor cells.
    [Stem Cell Reviews And Reports]

    Full ArticleGraphical Abstract

    Hepatocyte Growth Factor-Mediated Apoptosis Mechanisms of Cytotoxic CD8+ T Cells in Normal and Cirrhotic Livers

    Scientists found that hepatocyte growth factor secretion was significantly higher at 10 weeks post-diethylnitrosamine, the liver cirrhotic phase, than at three weeks post-diethylnitrosamine, the liver fibrotic phase.
    [Cell Death Discovery]

    Full Article

    Extracellular Vesicle-Mediated miR-126-3p Transfer Contributes to Inter-cellular Communication in the Liver Tumor Microenvironment

    Using both transwell and spheroid co‑cultures of liver cancer (LC) cells and hepatic stellate cells (HSCs), miR‑126‑3p within extracellular vesicles (EV) was established as a mediator of HSC to LC cell communication that influenced tumor cell migration and invasion.
    [International Journal Of Oncology]

    Full Article

    The PTBP1-NCOA4 Axis Promotes Ferroptosis in Liver Cancer Cells

    si‑PTBP1 introduction into sorafenib‑treated liver cancer cells resulted in a significant reduction in the levels of malondialdehyde and iron. Additionally, a significant recovery of GSH levels was observed after silencing PTBP1.
    [Oncology Reports]

    Abstract

    SERPINA12 Promotes the Tumorigenic Capacity of Hepatocellular Carcinoma Stem Cells through Hyperactivation of AKT/ β-Catenin Signaling

    Transcriptome profiling of epithelial-specific normal CD133+ cells isolated from fetal and regenerating liver against HCC CD133+ cells isolated from proto-oncogene driven and inflammation-associated HCC revealed preferential overexpression of SERPINA12 in HCC but not fetal and regenerating liver CD133+ cells.
    [Hepatology]

    Abstract

    Single-Cell Transcriptomics of Hepatic Stellate Cells Uncover Crucial Pathways and Key Regulators Involved in Non-Alcoholic Steatohepatitis

    Non-alcoholic steatohepatitis-associated transcriptomic change of HSCs was defined by single-cell RNA-sequencing (scRNA-seq) analysis, and those top upregulated genes were identified as NASH-associated transcriptomic signatures.
    [Endocrine Connections]

    Full Article

    Expression and Function of Myelin Expression Factor 2 in Hepatocellular Carcinoma

    ONCOMINE, HCCDB, and The Human Protein Atlas were used to identify myelin expression factor 2 (MYEF2) as a potential biomarker for HCC. The Cancer Genome Atlas database was used to further validate and analyze the value of MYEF2.
    [BMC Gastroenterology]

    Full Article
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    REVIEWS

    iPSC-Derived Liver Organoids and Inherited Bleeding Disorders: Potential and Future Perspectives

    Investigators explore the use of liver organoids as a state-of-the-art methodology for modeling coagulation factors disorders and the possibilities of using organoid technology to treat the disease.
    [Frontiers In Physiology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Researchers Receive $1.2 Million Grant to Study Link Between Gut Bacteria and Liver Disease

    Researchers from the University of Missouri School of Medicine have received $1.2 million from the National Institutes of Health to study how a diet high in fat and sugar may stimulate a type of gut bacteria to cause liver disease.
    [University of Missouri]

    Press Release

    NIH Grant Helps KU Provide Obesity and Metabolism Research Training for Pre-doctoral Graduate Students

    The University of Kansas Medical Center has been awarded a grant by the National Institutes of Health to provide training focused on obesity and metabolism for pre-doctoral graduate students.
    [The University of Kansas]

    Press Release
    FEATURED EVENT

    CAR-TCR Summit Europe

    February 21 – 23, 2023
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Digestion and Liver

    UT Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Research Fellow – Liver Organoids

    Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

    Postdoctoral Scientist – Cell Biology

    MRC National Institute for Medical Research – Cambridge, England, United Kingdom

    Postdoctoral Research Fellow – Chronic Liver Disease

    Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

    Faculty Position – Academic Gastrointestinal/Liver Pathologist

    University of Vermont – Burlington, Vermont, United States

    > See All Jobs

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