 | | Vol. 7.03 – 27 January, 2023 |
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| The authors show that hepatic steatosis aggravation shifts the hepatocellular death mode from apoptosis to necroptosis, causing increased hepatocellular death.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Applying Raman-spectroscopy and dynamic in silico modeling on the polyplex micelles, researchers determined the corona-core ratio (CCR) and visualized the possible micellar structure with varying CCR.
[Biomaterials] |
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| Ag(I) ion was found to be coordinated with the ligand’s oxygens in almost a linear fashion in complex, while in complex it adopted a tetrahedral geometry.
[Journal Of Inorganic Biochemistry] |
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| The authors investigated anti-fibrotic efficacy of exosomes derived from human adipose MSCs in vitro and in vivo, and identified important metabolic changes and the detailed mechanism through transcriptomic and metabolomic profiling.
[Journal Of Nanobiotechnology] |
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| Human hepatoma PLC/PRF/5-ASBT and THP1 cell lines or primary mouse hepatocytes were used for mechanistic studies. Hepatic TNFRSF12A expression was markedly increased in obstructive cholestasis or primary biliary cholangitis patients.
[Cell Death Discovery] |
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| Investigators utilized sorafenib resistant Huh7 cell line and LX2 hepatic stellate cell line to establish a sorafenib resistant 3D tumor spheroid model which could be used to test second-line treatment options.
[Cellular Signalling] |
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| YAP1 expression and autophagy constituted positive feedback, in which YAP1 inhibition decreased the autophagy activity in liver tumor cells by hepatocyte-specific Yap1 knockout mice.
[Experimental Cell Research] |
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| RNA-seq data from the Genotype-Tissue Expression Project and TCGA were analyzed in combination. In vitro cellular and molecular studies were conducted using SK-Hep-1 and Hep3B cells.
[Medical Science Monitor] |
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| Scientists found a higher HCC incidence in methamphetamine (METH) abusers. METH promoted cellular proliferation, migration, and invasion in two human-derived HCC cells.
[Life Science Alliance] |
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| Owing to several shortcomings like finite numbers of healthy organ donors, lifelong immunosuppression, and complexity of orthotopic liver transplantation, cell and cell-derivities therapies have emerged as a potential therapeutic alternative for a broad range of liver diseases.
[Expert Review Of Gastroenterology & Hepatology] |
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| Scientists discuss the relationship of protein tyrosine phosphatases (PTPs) with inflammatory cytokines and chemotherapy/targeted drug resistance, providing detailed information on how PTPs can modulate inflammatory reactions and drug resistance to influence progression in HCC.
[Oncology Reports] |
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| The Damon Runyon Cancer Research Foundation announced its newest class of Damon Runyon Fellows, 14 exceptional postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.
[Damon Runyon Cancer Research Foundation] |
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| April 14 – 19, 2023
Orlando, Florida, United States |
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| | Takeda Pharmaceutical Company – Boston, Massachusetts, United States |
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| | Imperial College London – London, United Kingdom |
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| | UT Southwestern Medical Center – Dallas, Texas, United States |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | MRC National Institute for Medical Research – Cambridge, England, United Kingdom |
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