 | | Vol. 7.04 – 3 February, 2023 |
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| The authors reported that Brahma-related gene 1 (Brg1) expression was elevated in mouse models of alcoholic liver disease (ALD), in hepatocytes exposed to alcohol, and in human ALD specimens.
[EMBO Molecular Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers sought to identify the new target that was involved in inflammation-related liver tumorigenesis. RNA-sequencing analysis was performed to identify the differential gene expression signature in primary human hepatocytes treated with or without inflammatory stimulus.
[Journal of Experimental & Clinical Cancer Research] |
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| The authors highlighted the biological importance of phospholipid catabolism driven by PNPLA8/PNPLA7 in methyl group flux and triglyceride synthesis in the liver.
[Cell Reports] |
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| Scientists demonstrated that HSCs are the source of neprilysin (NEP). Neuropeptide Y originated from the splanchnic region and was cleaved by NEP in order to terminate contraction.
[Cell Reports] |
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| Investigators reported that the level of 5-hydroxymethylcytosine (5-hmC) in human HCC tissues was significantly lower than that in adjacent liver tissues, and reduced 5-hmC significantly correlated with malignant phenotypes.
[Cell Death & Disease] |
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| Scientists used liver tissue, serum exosomes, and isolated hepatocytes from high-fat diet-induced Zucker diabetic fatty rats and leptin receptor knockout rats to investigate the correlation between hepatic leptin receptor defective and liver damage caused by metformin.
[Cell Death & Disease] |
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| Epithelial cell adhesion molecule/vimentin/Glypican-3 antibody-modified lipid magnetic spheres were used to capture tumor cells with epithelial phenotype in order to capture more circulating tumor cells with a more comprehensive phenotype for monitoring tumor metastasis.
[Journal of Nanobiotechnology] |
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| Investigators observed that the expression of PIMT was upregulated in the livers of short-term fasted and obese mice.
[iScience] |
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| Researchers reported a comparative study of hepatic spheroids generated from freshly isolated mouse whole liver cells and hepatocytes.
[Disease Models & Mechanisms] |
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| The authors explore the molecular mechanism associated with HCC development, summarize targeted therapies for HCC, and discuss potential biomarkers that may drive therapies.
[Cancer and Metastasis Reviews] |
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| A panel of experts joined a meeting of the US National Science Advisory Board of Biosecurity, discussing on issues such as how privately funded risky research would be regulated, the role of research institutions in identifying potentially dangerous research, and much more.
[Nature] |
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| February 22 – 23, 2023
Boston, Massachusetts, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Mississippi Medical Center – Jackson, Mississippi, United States |
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| | University of Illinois Chicago – Chicago, Illinois, United States |
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| | UNC-Greensboro – Kannapolis, North Carolina, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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