 | | Vol. 7.06 – 17 February, 2023 |
| |
|
|
| Scientists uncovered that periportal-specific liver progenitor-like cell formation was initiated by regionally activated Kupffer cells but not peripheral monocyte-derived macrophages.
[Cell Stem Cell] |
|
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers demonstrated that scaffolds crosslinked with nano-graphene oxide show high resistance to enzymatic degradation via direct inhibition of matrix metalloproteinase activity and increased mechanical rigidity.
[Nature Communications] |
|
|
|
| Investigators tested the susceptibility of seven mouse strains to develop non-alcoholic steatohepatitis (NASH). The severity of the clinical phenotypes observed varied widely across strains.
[Journal of Experimental Medicine] |
|
|
|
| Hepatic steatosis was analyzed by Nile Red staining and measurement of inflammatory cytokines. Lipid accumulation and cell death were evaluated in co-culture systems with primary hepatocytes and Kupffer cells derived from either Ttp+/+ or Ttp−/− mice.
[Metabolism Clinical And Experimental] |
|
|
|
| Researchers detected widespread expression of shared TP53-Y220C neoantigen in HCC with low affinity and low stability of binding to HLA-A0201 molecules.
[European Journal of Immunology] |
|
|
|
| The authors aimed to confirm the biological roles of seven in absentia homolog 2 (SIAH2) in liver cancer and provide potential therapeutic targets. Differential analysis was conducted based on public datasets and found that SIAH2 expressed lowly in HCC samples relative to normal tissues.
[Experimental Cell Research] |
|
|
|
| Investigators found that Tubulin γ-1 (TUBG1) was upregulated in human HCC cells and tissues and that TUBG1 upregulation was associated with promoter hypomethylation in HCC tissues.
[Medical Oncology] |
|
|
|
| Scientists evaluated the role of NLRP3 inflammasome and pyroptosis in HCC and to clarify the potential mechanism by which 17β-estradiol could be used as a protective factor against HCC.
[Medical Oncology] |
|
|
|
| Researchers used Airyscan super-resolution microscopy and correlative light-electron microscopy to characterize parkin association during photodamage-induced mitophagy, a form of phosphoinositide 3-kinase-independent or Type 2 mitophagy.
[Biophysical Journal] |
|
|
|
|
| Scientists describe the origin as well as phenotypic heterogeneity of tumor-associated macrophages (TAMs) and their potential effects on the occurrence and development of HCC and also discuss various adjuvant therapy-based strategies that can be used for targeting TAMs.
[Cell Death Discovery] |
|
|
|
|
| Arrowhead Pharmaceuticals, Inc. announced that it has gained rights to ARO-PNPLA3, formerly called JNJ-75220795, which was part of a 2018 research collaboration and option agreement between Arrowhead and Janssen Pharmaceuticals, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson.
[Arrowhead Pharmaceuticals, Inc.] |
|
|
|
|
| March 31, 2023
Amsterdam, The Netherlands |
|
|
|
|
|
| | Twincore GmbH – Hannover, Germany |
|
|
|
| | University of Alberta – Edmonton, Alberta, Canada |
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | University of Mississippi Medical Center – Jackson, Mississippi, United States |
|
|
|
| | University of Illinois Chicago – Chicago, Illinois, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
