 | | Vol. 7.08 – 10 March, 2023 |
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| Researchers conducted in vitro experiments and found that tamoxifen protected hepatocytes against sodium palmitate-induced lipotoxicity.
[Signal Transduction and Targeted Therapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors designed amphiphilic peptide-modified glutathione-gold nanocluster aggregates with the enrichment of solid liver tumors and the prolonged stress in the endoplasmic reticulum.
[Advanced Materials] |
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| Researchers showed that while chronic alcohol-induced NLRP3 inflammasome activation in the liver, alcohol binge resulted not only in NLRP3 inflammasome activation but also in increased circulating extracellular ASC specks and hepatic ASC aggregates.
[Hepatology] |
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| Scientists showed the role of p53 in regulating ethanol metabolism via acetaldehyde dehydrogenase 2 (ALDH2), a key enzyme responsible for the oxidization of alcohol.
[EMBO Journal] |
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| Researchers found that ROCK (Rho-associated kinase) inhibitors significantly enhanced in vivo hepatocyte engraftment. Mechanistic studies suggested that the isolation of hepatocytes caused substantial degradation of cell membrane proteins.
[Molecular Therapy] |
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| Investigators determined the effect of macrophage necroptosis in biliary atresia (BA) pathology and explored the specific molecular mechanism. They found that necroptosis existed in BA livers, which occurred in liver macrophages.
[Cell Death & Disease] |
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| The authors reported that SIRT3 could delactylate non-histone proteins and suppress HCC development. Using SILAC-based quantitative proteomics, they identified cyclin E2 as one of the lactylated substrates of SIRT3 in HCC cells.
[EMBO Reports] |
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| Investigators evaluated the effects of melatonin on cell cytotoxicity and proliferation, colony formation, morphological and immunohistochemical aspects, and on glucose consumption and lactate release.
[Life Sciences] |
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| Scientists found ribonucleotide reductase subunit M2 (RRM2) was one of the key genes supporting cell proliferation in high-risk hepatoblastoma.
[Communications Biology] |
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| Investigators explored the role of hepatic Zinc Finger And BTB Domain Containing 22 (ZBTB22) in defense against Acetaminophen-mediated hepatotoxicity.
[iScience] |
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| Researchers demonstrated that periplocymarin synchronously activated lethal apoptosis and protective autophagy in liver cancer, and the initiation of autophagy counteracted the inherent pro‑apoptotic capacity and impaired the anti‑cancer effects.
[International Journal Of Oncology] |
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| Investigators discuss the concept that autoimmune sclerosing cholangitis and primary sclerosing cholangitis (PSC)/autoimmune hepatitis-overlap are not distinct entities. Rather, they represent inflammatory phases of PSC frequently manifesting earlier in disease course.
[Journal of Hepatology] |
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| Scientists outline current immune checkpoint inhibitors (ICI) treatments for HCC and how ICIs can be combined with distinct epigenetic inhibitors to increase the durability of ICIs and potentially treat “immune-cold” HCC.
[Oncogene] |
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| The authors discuss the pyroptosis pathways and pyroptosis-related components, as well as the role of pyroptosis and its components in HCC. Finally, they review the therapeutic significance of pyroptosis in HCC.
[Cellular Oncology] |
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| The total cost of cancer to the global economy will reach 25.2 trillion international dollars between 2020 and 2050, according to an analysis of 29 cancers across 204 countries.
[Nature] |
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| April 24 – 26, 2023
Hinxton, England, United Kingdom |
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| | The German Cancer Research Center – Heidelberg, Germany |
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| | University of Vermont – Burlington, Vermont, United States |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | University of Missouri – Columbia, Missouri, United States |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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