 | | Vol. 7.09 – 17 March, 2023 |
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| Researchers identified a transitional liver progenitor cell, which originated from biliary epithelial cells and differentiated into hepatocytes during regeneration from severe liver injury.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using high-throughput screens, proteomics and in vitro resistance models, investigators identified the small molecule YC-1 as selectively active against a defined subset of cell lines derived from both liver cancer types.
[Nature Cancer] |
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| The authors demonstrated that phosphoenolpyruvate carboxykinase 1 (PCK1) played a central role in metabolic-associated fatty liver disease progression.
[Nature Communications] |
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| Scientists proposed that two Hippo signaling modules, MST1/2–SAV1–WWC1-3 and MAP4K1-7–NF2, together regulated the activity of LATS1/2 kinases and YAP/TAZ transcriptional co-activators.
[EMBO Journal] |
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| Researchers explored the role of interleukin-33 (IL-33) role in HCC and identified that a posttranslational modification altered its nuclear activity and promoted immune escape for HCC.
[Science Signaling] |
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| Deletion of Diaphanous 1 (Diaph1) attenuated expression of genes regulating hepatic lipid metabolism without effect on mRNA expression of upstream transcription factors in male mice.
[Communications Biology] |
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| Scientists suggested the CAR T cells could specifically eliminate Tn-MUC1-positive intrahepatic cholangiocarcinoma (ICC) cells, but not Tn-MUC1-negative ICC cells, in vitro and in vivo.
[Journal Of Immunotherapy] |
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| MUC13 was upregulated in HCC and liver cancer stem cells (CSCs) and had a positive influence on CSC generation. Further analyses revealed that MUC13 with promoter hypomethylated was regulated by DNA demethylase TET3.
[Epigenomics] |
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| Investigators found that Cu2-xSe nanoparticles inhibited the proliferation of HepG2 and SMMC-7721 cells and mainly induced cell cycle arrest at the G2/M phase.
[Biomedical Materials] |
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| The authors present the latest knowledge of the pathogenic mechanisms and clinical management of nonalcoholic steatohepatitis-HCC.
[Nature Reviews Gastroenterology & Hepatology] |
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| Researchers from the University of Sydney have been awarded $47 million to support 32 research projects, including investigations of younger-onset dementia, the treatment of blinding eye diseases through stem cell therapy, and the impact of e-cigarette use by adolescents.
[The University of Sydney] |
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| The National People’s Congress and the Chinese People’s Political Consultative Conference have boosted science and technology in the national agenda.
[Nature] |
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| April 25 – 26, 2023
London, England, United Kingdom |
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| | Johns Hopkins University – Baltimore, Maryland, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | University of Vermont – Burlington, Vermont, United States |
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| | The German Cancer Research Center – Heidelberg, Germany |
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| | University of Missouri – Columbia, Missouri, United States |
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