Hepatic Cell News Volume 7.10 | Mar 24 2023

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    2023-03-24 | HCN 7.10


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.10 – 24 March, 2023
    TOP STORY

    Acute Liver Steatosis Translationally Controls the Epigenetic Regulator MIER1 to Promote Liver Regeneration in a Study with Male Mice

    Scientists identified an epigenetic mechanism by which the early phase lipid redistribution from adipose tissue to the liver during regeneration impacted hepatocyte proliferation.
    [Nature Communications]

    Full Article
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    Secreted Protease PRSS35 Suppresses Hepatocellular Carcinoma by Disabling CXCL2-Mediated Neutrophil Extracellular Traps

    Researchers showed that the secreted pseudo serine protease PRSS35 functioned as a tumor suppressor in HCC. Mechanistically, they demonstrated that active PRSS35 was processed via cleavage by proprotein convertases.
    [Nature Communications]

    Full Article

    Parathyroid Hormone Receptor-1 Signaling Aggravates Hepatic Fibrosis through Upregulating cAMP Response Element Binding Protein-Like 2

    Investigators examined the role of parathyroid hormone receptor-1 signaling in the activation of hepatic stellate cells and hepatic fibrosis.
    [Hepatology]

    AbstractGraphical Abstract

    Targeting WDxR Motif Reprograms Immune Microenvironment and Inhibits Hepatocellular Carcinoma Progression

    WD-repeat 6 (WDR6) deficiency in hepa1-6 cells drastically inhibited the growth and lung metastasis of orthotopically implanted tumors in immune-competent C57BL/6J mice.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    GPAT3 Regulates the Synthesis of Lipid Intermediate LPA and Exacerbates Kupffer Cell Inflammation Mediated by the ERK Signaling Pathway

    Researchers reported that glycerol-3-phosphate acyltransferase 3 (GPAT3) played a key role in Kupffer cells (KCs) inflammation response. Their findings indicated that lipopolysaccharide-mediated inflammatory activation markedly increased lipid droplets accumulation in KCs.
    [Cell Death & Disease]

    Full Article

    LncRNA-MIAT Activates Hepatic Stellate Cells via Regulating Hippo Pathway and Epithelial-to-Mesenchymal Transition

    The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.
    [Communications Biology]

    Full Article

    KIFC3 Regulates Progression of Hepatocellular Carcinoma via EMT and the AKT/mTOR Pathway

    The authors found that the expression of KIFC3 was upregulated in HCC, and high KIFC3 expression was related to poor overall survival.
    [Experimental Cell Research]

    Abstract

    LncRNA MBNL1-AS1 Knockdown Increases the Sensitivity of Hepatocellular Carcinoma to Tripterine by Regulating miR-708-5p-Mediated Glycolysis

    Scientists proved that LncRNA MBNL1-AS1 increased the tripterine resistance of HCC cells at least partly by mediating miR-708-5p-related glycolysis.
    [Biotechnology and Genetic Engineering Reviews]

    Abstract

    Circular RNA hsa_circ_0005218 Promotes the Early Recurrence of Hepatocellular Carcinoma by Targeting the miR-31-5p/CDK1 Pathway

    High-throughput RNA-sequencing analysis was conducted to identify the expression profile of circRNAs in HCC tissues and circ_0005218 was identified as one circRNA that significantly up-regulated in early recurrent HCC tissues.
    [Heliyon]

    Full Article
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Emerging Targets for Therapy in ALD: Lessons from NASH

    Scientists describe conserved and distinct pathogenic pathways highlighting therapeutic targets which may be of potential in both alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease, and those which are unique to each disease.
    [Hepatology]

    Abstract

    Emerging Role of Lipophagy in Liver Disorders

    The authors summarize the recent studies focusing on various components of the lipophagic machinery that can be modulated for their potential role as therapeutic agents against a wide range of liver diseases.
    [Molecular and Cellular Biochemistry]

    Abstract
    INDUSTRY AND POLICY NEWS

    89bio’s Phase IIb ENLIVEN Trial of Pegozafermin in Nonalcoholic Steatohepatitis (NASH) Achieved High Statistical Significance on Both Primary Histology Endpoints with Weekly (QW) and Every-Two-Week (Q2W) Dosing at 24 Weeks

    89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
    [89bio, Inc.]

    Press Release
    FEATURED EVENT

    Integrative Molecular Epidemiology Workshop: Bridging Cancer Biology and Precision Medicine

    July 24 – 28, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Cancer Research and Tumor Immunology

    Umeå University – Umeå, Sweden

    Postdoctoral Research Fellow – Tumor-on-Chip Metastasis Model

    Oslo University Hospital – Oslo, Norway

    Postdoctoral Fellow – Liver Cancer Biology

    Boston Children’s Hospital – Boston, Massachusetts, United States

    Research Postdoctoral Fellow – Fatty Liver Development

    Johns Hopkins University – Baltimore, Maryland, United States

    Academic Pathologist – Liver Pathology

    University of Vermont – Burlington, Vermont, United States

    > See All Jobs

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