 | | Vol. 7.11 – 31 March, 2023 |
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| Researchers dissected the cellular and molecular basis underlying hepatoblastoma (HB) oncogenesis and heterogeneity at the single‐cell level, which could facilitate a better understanding of HB at both the biological and clinical levels.
[Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists engineered a genetically engineered mouse in which IL‐15R complementary DNA had been inserted in‐frame with lecithin‐retinol acyltransferase gene and bred onto an IL‐15R‐KO genetic background that expressed IL‐15R in hepatic stellate cells at normal levels.
[Hepatology] |
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| The authors characterized a functional link of age-mediated defects in SIRT1 to the NLRP3 inflammasome during age-related liver fibrosis.
[Aging Cell] |
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| The inhibition of ferroptosis signaling synergized with bortezomib, a clinically used proteasome inhibitor, to suppress the viability of HCC cells in vitro and in vivo.
[Free Radical Biology and Medicine] |
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| Investigators prepared a hollow manganese dioxide (MnO2) nanoprobes loaded with photosensitive drug IR780 for the photothermal/photodynamic/chemodynamic co-therapy of liver cancer.
[Pharmaceutical Research] |
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| The authors investigated the effect of leucine-rich repeat-containing G-protein-coupled receptors 4 (LGR4) with epidermal growth factor receptor (EGFR) in HCC cells.
[Cytokine] |
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| Researchers treated HCC cells with transforming growth factor-β and characterized the cellular processes associated with epithelial to mesenchymal transition.
[Heliyon] |
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| The cytotoxic effect of the purified enzyme was evaluated in vitro against a panel of human tumor cell lines and in vivo against male Wister albino mice intraperitoneally injected with diethyl nitrosamine.
[The Journal Of Genetic Engineering And Biotechnology] |
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| Stratifin was highly expressed in the tissues and serum of HCC, and its expression level was correlated with the tumor which was single or not in patients.
[Tissue and Cell] |
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| Investigators describe the current development of 3D liver models that can be used to test drugs/chemicals for their pharmacologic and toxicologic effects.
[Cell Reports Methods] |
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| Scientists review the role of N-glycosylation in hepatocarcinogenesis, focusing on epithelial-mesenchymal transition, extracellular matrix changes, and tumor microenvironment formation.
[Cell Death & Disease] |
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| Omega Therapeutics, Inc. announced a clinical supply agreement with Roche to evaluate OTX-2002, its lead candidate in development for the treatment of MYC-driven HCC, in combination with Roche’s anti-PD-L1 therapy, atezolizumab, as part of Omega’s Phase I/II MYCHELANGELO™ I clinical trial.
[Omega Therapeutics, Inc.] |
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| | The University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | Umeå University – Umeå, Sweden |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Oslo University Hospital – Oslo, Norway |
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| | Johns Hopkins University – Baltimore, Maryland, United States |
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