 | | Vol. 7.12 – 14 April, 2023 |
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| The authors examined the association between clonal hematopoiesis of indeterminate potential and chronic liver disease in 214,563 individuals from four fourindependent cohorts with whole-exome sequencing data.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To interrogate genes in human metabolic disease, researchers performed lineage tracing in mice harboring somatic mosaicism subjected to nonalcoholic steatohepatitis.
[Cell] |
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| Investigators provided a detailed proteo-transcriptomic map of steatohepatitis and fibrosis during progressive non-alcoholic fatty liver disease.
[Nature Metabolism] |
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| Researchers analyzed publicly available patient databases and liver biopsies. They employed transgenic mice, in which genes were deleted only in activated HSCs to perform ex vivo analysis and animal models.
[Hepatology] |
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| The authors developed a multifocal HCC model to test immunotherapies by introducing c-myc using hydrodynamic gene transfer along with CRISPR-Cas9-mediated disruption of p53 in mouse hepatocytes
[Cell Reports Medicine] |
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| The authors presented an in vivo scaffold fabrication approach by minimally invasive bioprinting electroactive hydrogel scaffolds to promote in situ tissue regeneration.
[Bioactive Materials] |
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| A targeted therapeutic strategy is presented for potentiating tumor vascular normalization and systematic chemo-immunotherapy to effectively inhibit the progression of HCC in both orthotopic model and patients-derived organoids.
[Small] |
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| By treating primary human hepatocytes with the monounsaturated fatty acid oleate, researchers showed that lipid droplets were intracellular mechanical stressors with similar effects to tissue stiffening, including nuclear deformation, chromatin condensation, and impaired hepatocyte function.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| In the dimethylnitrosamine-induced HCC mouse model, hepatocyte-specific depletion of Ppancreatic progenitor cell differentiation and proliferation factor (Ppdpf) promoted hepatocarcinogenesis, and reintroduction of PPDPF into liver-specific Ppdpf knockout mice inhibits the accelerated HCC development.
[Cell Reports] |
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| Investigators extracted data from TGCA database and validated RNF2 expression in teir cohort, which revealed that RNF2 was highly expressed in HCC and was associated with malignant characteristics and poor prognosis of HCC.
[Cell Death & Disease] |
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| Researchers discovered the inhibitory effect of SIAH1 on HCC cell migration and invasion, which was related with regulating EMT. Molecularly, a yeast two-hybrid experiment indicated that CTR9 was a potential interacting protein of SIAH1, which was further verified by co-immunoprecipitation assays.
[Carcinogenesis] |
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| The authors characterized mRNA expression and activity of main hepatic drug transporters in cryopreserved human hepatocytes isolated from chimeric TK-NOG mice and termed HepaSH cells.
[Toxicology In Vitro] |
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| Scientists discuss mechanisms that regulate carbohydrate-responsive element-binding protein activity in a tissue-specific manner and their respective roles in controlling de novo lipogenesis and beyond.
[Nature Reviews Endocrinology] |
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| Queen’s researchers are among five teams receiving $29 million from the Canadian Cancer Society to jumpstart innovative research and radically change the outcomes for six of the most common and deadly cancers.
[Queen’s University] |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | The University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | Umeå University – Umeå, Sweden |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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