 | | Vol. 7.14 – 28 April, 2023 |
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| Researchers described that hepatocyte dedifferentiation was associated with disease severity and a reduced synthetic capacity of the liver. Moreover, they identify the CXCR4 pathway as a driver of hepatocyte dedifferentiation and as a therapeutic target in alcohol-related hepatitis.
[Journal Of Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| A biomimetic nano-regulator was developed to affect both collagen synthesis and degradation in the liver to remodel the collagen microenvironment. Scientists found that Zn (II) interference could efficiently inhibit collagen synthesis in activated hepatic stellate cells, affecting many fibrosis-related signaling pathways.
[Advanced Science] |
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| Investigators used transcriptomic profiles from liver fibrosis cases of different etiologies, to identify and validate liver fibrosis-specific matrisome genes, and their clinical and biological relevance.
[Hepatology] |
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| Scientists found that the expression of CD36 in hepatocytes was increased in patients and a mouse model with sepsis, accompanied by impaired autophagy flux.
[Autophagy] |
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| Investigators found that in advanced HCC tissues, collagen I was upregulated, which was consistent with the expression of its receptor DDR1. Collagen I-induced DDR1 activation enhanced HCC cell stemness in vitro and in vivo.
[Cell Death & Differentiation] |
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| Researchers suggested that TNF-α/IL-1β pretreatment enhances the efficacy of adipose tissue-derived stem cells in mice with cholestatic liver injury, partially through the COX-2/PGE2 pathway.
[Stem Cell Research & Therapy] |
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| Scientists found that KDM4C protein expression was increased in HCC and promotes HCC cell growth, proliferation, and migration.
[Cell Death Discovery] |
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| SYVN1 regulated FoxO1 ubiquitination to stimulate β-catenin nuclear translocation and promoted PD-L1-mediated metastasis and immune evasion in HCC.
[Cellular Oncology] |
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| Researchers analyzed the oncogenic and immunologic roles of SPP1 and CSF1 in HCC. They found that the expression levels of SPP1 and CSF1 in HCC were markedly increased and positively correlated.
[Medical Oncology] |
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| The authors summarize the current status of research on the role of exosomes in liver fibrosis with a review of relevant literature and key findings.
[Journal Of Gastroenterology And Hepatology] |
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| Lorraine Stiehl, Chief Executive Officer of the American Liver Foundation, applauds the reintroduction of the Living Donor Protection Act of 2023, which will help protect living organ donors from discrimination in insurance and ensure living donors can take time off for organ donation and recovery.
[American Liver Foundations] |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University of Reading – Reading, England, United Kingdom |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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