Hepatic Cell News Volume 7.15 | May 05 2023

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    Jamie Kang
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    2023-05-05 | HCN 7.15


    Hepatic Cell News by STEMCELL Technologies
    Vol. 7.15 – 5 May, 2023
    TOP STORY

    Targeting Fibrinogen-Like Protein 1 Enhances Immunotherapy in Hepatocellular Carcinoma

    Scientists reported that fibrinogen-like protein 1, a newly identified immune checkpoint ligand, was modified by acetylation at Lys 98 in HCC, which targeted it for proteasomal degradation.
    [Journal Of Clinical Investigation]

    Full ArticleGraphical Abstract
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    PUBLICATIONSRanked by the impact factor of the journal

    Organoid Models of Fibrolamellar Carcinoma Mutations Reveal Hepatocyte Transdifferentiation Through Cooperative BAP1 and PRKAR2A Loss

    Investigators generated a set of human hepatocyte organoid models engineered to reflect different genetic backgrounds as identified in fibrolamellar carcinoma (FLC) or FLC-like cases.
    [Nature Communications]

    Full ArticlePress Release

    Extrachromosomal Circular MiR-17-92 Amplicon Promotes Hepatocellular Carcinoma

    Researchers provided a comprehensive characterization of extrachromosomal circular DNAs (eccDNAs) in human HCC and demonstrated an oncogenic role of microRNA-17-92-containing eccDNAs in tumor progression.
    [Hepatology]

    AbstractGraphical Abstract

    Activation of ACLY by SEC63 Deploys Metabolic Reprogramming To Facilitate Hepatocellular Carcinoma Metastasis Upon Endoplasmic Reticulum Stress

    Investigators explored the pivotal roles of SEC63-mediated metabolic remodeling in HCC cell metastasis after endoplasmic reticulum stress.
    [Journal Of Experimental & Clinical Cancer Research]

    Full Article

    Loss of Ufl1/Ufbp1 in Hepatocytes Promotes Liver Pathological Damage and Carcinogenesis Through Activating mTOR Signaling

    Investigators revealed the potential role of Ufm1-specific ligase and Ufm1-binding protein 1 as gatekeepers to prevent liver fibrosis and subsequent steatohepatitis and HCC development by inhibiting the mTOR pathway.
    [Journal Of Experimental & Clinical Cancer Research]

    Full Article

    Downregulated Liver-Elevated Long Intergenic Noncoding RNA (LINC02428) Is a Tumor Suppressor That Blocks KDM5B/IGF2BP1 Positive Feedback Loop in Hepatocellular Carcinoma

    Scientists reported the roles and mechanisms of downregulated liver-elevated (LE) LINC02428 in HCC. Downregulated LE lncRNAs played significant roles in HCC genesis and development.
    [Cell Death & Disease]

    Full Article

    CD14 Is Not Required for Carbon Tetrachloride-Induced Hepatic Inflammation and Fibrosis With or Without Lipopolysaccharide Challenge

    Scientists investigated the effects of lipopolysaccharide on carbon tetrachloride-induced fibrosis in CD14-knockout mice in vivo, and culture-activated hepatic stellate cells in vitro.
    [Journal Of Cellular Physiology]

    Abstract

    Sclareol Attenuates Liver Fibrosis Through SENP1-Mediated VEGFR2 SUMOylation and Inhibition of Downstream STAT3 Signaling

    Researchers evaluated the anti-fibrotic activity of sclareol and explored its underlying mechanisms. Stimulated hepatic stellate cells served as an in vitro liver fibrosis model.
    [Phytotherapy Research]

    Abstract

    Identification of PPT1 as a Lysosomal Core Gene With Prognostic Value in Hepatocellular Carcinoma

    Investigators identified key lysosome-related genes affecting HCC. Lysosome-related genes involved in HCC progression were screened based on the TCGA dataset.
    [Bioscience Reports]

    Abstract
    Free Wallchart: Dynamic Modeling in Organoids
    REVIEWS

    Stellate Cell in Hepatic Inflammation and Acute Injury

    The authors highlight the crosstalk between hepatic stellate cells and other hepatic cells in orchestrating acute hepatic injury and discuss how findings from recent studies provide insights into potential therapeutic approaches.
    [Journal Of Cellular Physiology]

    Full ArticlePress Release

    Liquid Biopsy Using Cell-Free DNA in the Early Diagnosis of Hepatocellular Carcinoma

    Investigators summarize the latest research progress of liquid biopsy based on blood cell-free DNA in early screening of HCC.
    [Investigational New Drugs]

    Abstract
    INDUSTRY AND POLICY NEWS

    MediciNova Receives a Notice of Allowance for a New Patent Covering MN-001 for the Treatment of Advanced NASH in Canada

    MediciNova, Inc. announced it has received a Notice of Allowance from the Canadian Intellectual Property Office for a pending patent application that covers MN-001, tipelukast, for the treatment of advanced nonalcoholic steatohepatitis (NASH).
    [MediciNoca, Inc.]

    Press Release
    FEATURED EVENT

    Diversity in a Dish: Pluripotent Stem Cells in Genetic Analysis and Disease Modeling

    May 23 – 25, 2023
    Bar Harbor, Maine, United States & Virtual

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    JOB OPPORTUNITIES

    Director – Liver Transplant

    University of Utah – Salt Lake City, Utah, United States

    Postdoctoral Research Associate – Oncology

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Research Associate – Alcohol Related Liver Disease

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Studentship – Platelet Function in Liver Disease

    University of Reading – Reading, England, United Kingdom

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    > See All Jobs

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