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| Scientists reported that selective ablation of stearoyl CoA desaturase-2 in activated hepatic stellate cells globally suppressed nuclear CTNNB1 and YAP1 in tumors and tumor microenvironment and prevented liver tumorigenesis in male mice.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that hypoxia-inducible factor 1 orchestrated adenosine efflux through two steps in HCC. Multiple in vitro assays demonstrated the immunosuppressive role of adenosine on T cells and myeloid cells.
[Science Advances] |
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| Researchers determined whether the E3 ubiquitin ligase Ring Finger Protein 125 (RNF125) played a role in the proliferation and metastasis of HCC. RNF125 expression in human HCC samples and cell lines was investigated using TCGA dataset mining, qRT‒PCR, western blot, and immunohistochemistry assays.
[Oncogene] |
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| Self-assembling nanoparticles (NPs) composed of amphiphilic polymers were introduced to encapsulate organic Selenium compound L-Se-methylselenocysteine (SeMC) and form SeMC NPs, which protected the viabilities and functions of cultured hepatocytes in drug- or chemical-induced acute hepatotoxicity models.
[Cell Proliferation] |
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| Scientists provided evidence that depletion of KDM4C led to a defective G2/M checkpoint, increased radiation-induced DNA damage, impaired DNA repair, and enhanced radiosensitivity in HCC cells.
[Cell Death Discovery] |
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| Researchers identified a potential strategy and provide a fundamental experimental basis for treating hepatic ischemia/reperfusion (I/R) injury. They found that tripartite motif containing 37 (TRIM37) aggravated hepatic I/R injury through the reinforcement of IKK-induced inflammation following dual patterns.
[Molecular Medicine] |
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| Investigators found that cellular communication network factor 5 (CCN5) was expressed in hepatic stellate cells, myofibroblasts, and portal myofibroblasts, while CCN5 expression was virtually absent in hepatocytes
[Journal Of Cell Communication And Signaling] |
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| Researchers prepared hyaluronic acid (HA)-coated micelles entrapping olmesartan medoxomil, an anti-fibrotic drug, and evaluated their possibility as drug delivery vehicles. HA-coated micelles exhibited specific cellular uptake into LX-2 cells in vitro.
[ACS Biomaterials Science & Engineering] |
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| Scientists elucidated the molecular mechanism of LncTUG1 in the regulation of HCC evolvement. They suggested that LncTUG1 targets miR-144-3p while miR-144-3p binds to RRAGD mRNA, which induces mTOR/S6K pathway activation and promotes the progression of HCC.
[Scientific Reports] |
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 | | | The authors summarize evidence on the epidemiology and pathophysiology of nonalcoholic fatty liver disease-associated HCC and critically summarize the currently available options for its prevention and treatment.
[Seminars In Cancer Biology] |
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Investigators summarize available data on the treatment of patients with HCC and moderate liver dysfunction. Opportunities, as well as clinical challenges, are discussed in detail, highlighting potential changes to the therapeutic landscape.
[Cancer Medicine] |
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| A $1.35 million gift from Scotiabank to the McGill University Health Centre (MUHC) Foundation helped to fund Montréal sans HépC, an innovative new program that aims to eliminate hepatitis C in Montreal through community-based advocacy and health care.
[Scotiabank] |
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| May 28 – 31, 2023
Killarney, Ireland |
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| | Helmholtz Association of German Research Centres – Heidelberg, Germany |
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| | University of Geneva – Geneva, Switzerland |
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| | University of Utah – Salt Lake City, Utah, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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