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| A ferrimagnetic vortex-domain iron oxide nanoring-based nanovehicle was developed that was able to deliver high-mobility group protein A1 (HMGA1) small interfering RNA to the cytoplasm of hepatocellular carcinoma Hepa 1–6 cells for HMGA1 pathway interference.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| By single-cell RNA sequencing of 13 treatment-naive hepatoblastoma patients, scientists discovered an immune landscape characterized by aberrant accumulation of erythroblastic islands, formed by VCAM1+ macrophages and erythroid cells.
[Cell Reports Medicine] |
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| Researchers found that COVID-19 was independently associated with in-hospital hyperglycemia and that SARS-CoV-2 was capable of infecting hepatocytes and stimulating these cells to produce glucose through gluconeogenesis.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators discovered a novel CT-lncRNA, LINC01977, based on the Genotype-Tissue Expression and The Cancer Genome Atlas databases. LINC01977 was exclusively expressed in testes and highly expressed in HCC.
[Cell Death Discovery] |
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| Scientists assessed the role of angiopoietin-like protein (ANGPTL) 8, a protein secreted by HCC cells, in hepatocarcinogenesis and the mechanisms through which ANGPTL8 mediated crosstalk between HCC cells and tumor-associated macrophages.
[Oncogenesis] |
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| In both early (I and II) and late (III and IV) stages of HCC, a high E2F score was associated with worse survival and was an independent prognostic factor for overall and disease-specific survival in patients with HCC.
[Surgery] |
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| The role of intraoperative blood auto-transfusion in regulating the recovery of liver cancer was investigated using a rat model of liver cancer and an intraoperative blood return model. Kupffer cells were isolated from liver cancer tissues, and their biological characteristics were analyzed by flow cytometry.
[Biotechnology and Genetic Engineering Reviews] |
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| To overcome issues of low proliferative capacity and difficulty in passaging due to loss of hepatic functions after reseeding hepatocyte-like cells (HLCs), scientists developed technology to dissociate, cryopreserve, and reseed HLCs in this study.
[PLOS One] |
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| Researchers investigated the effects of orientin on the viability, proliferation, and migration of HCC cells in vitro. They found that orientin could inhibit the proliferation, migration, and the activation of NF-κB signaling pathway in HCC cells.
[Naunyn-Schmiedebergs Archives Of Pharmacology] |
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| The authors critically discuss the particularities in the management of patients with non-alcoholic fatty liver disease (NAFLD)-related cirrhosis.
[Hepatology] |
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| Elevar Therapeutics, Inc announced it submitted a New Drug Application to the US FDA for its investigational drug rivoceranib, an oral TKI, in combination with camrelizumab, a PD-1 inhibitor, as a first-line treatment option for unresectable HCC.
[Elevar Therapeutics, Inc.] |
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| June 2 – 6, 2023
Chicago, Illinois, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
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| | Helmholtz Association of German Research Centres – Heidelberg, Germany |
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| | University of Geneva – Geneva, Switzerland |
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| | University of Utah – Salt Lake City, Utah, United States |
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