 | | Vol. 7.21 – 16 June, 2023 |
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| Scientists showed that itaconic acid was upregulated in human non-alcoholic steatohepatitis and a mouse model of non-alcoholic fatty liver disease.
[Nature Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Through cross-omics analysis, yin yang 2 (YY2) was identified as a novel negative regulator of cancer stem cell maintenance. It was shown that YY2 was downregulated in stem-like tumor spheres formed by hepatocarcinoma cells and in liver cancer.
[Advanced Science] |
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| The authors showed that recombinant adeno-associated virus (AAV) injection caused liver injury, hepatic necroptosis, and HCC in db/db or high-fat diet-induced hyperglycemic and obese mice, but not in mice with only hyperglycemia or obesity.
[EMBO Molecular Medicine] |
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| Bioinformatics analyses and immunohistochemistry assay were employed to identify organic cation/carnitine transporter 2 (OCTN2) expression in HCC tissues. The correlation between OCTN2 expression and prognosis was elucidated through K-M survival analysis.
[Metabolism Clinical And Experimental] |
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| Bioinformatics analysis identified miR-494 metabolic targets. QPCR analysis of glucose 6-phosphatase catalytic subunit (G6pc) was performed in HCC patients and preclinical models.
[Journal of Experimental & Clinical Cancer Research] |
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| The expression of C-type lectin domain family 1 member B (CLEC1B) was explored using The Cancer Genome Atlas and Gene Expression Omnibus databases. RT-qPCR, western blot, and immunohistochemistry assays were employed to validate the downregulation of CLEC1B.
[Cancer Cell International] |
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| TATA-box-binding protein expression was measured by PCR, western blot, and immunohistochemistry. RNA-sequencing was performed to identify downstream proteins.
[Hepatology Communications] |
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| In HCC tissues, differentially expressed long noncoding RNAs (lncRNAs) were identified by bioinformatics. AC012360.1 level was validated and its role in HCC progression was investigated.
[Environmental Toxicology] |
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| The levels of circular RNA basonuclin 2 and high mobility group AT-hook 2 were highly expressed, while those of miR-217 were poorly expressed in HCC tissues and cells.
[Heliyon] |
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| The authors describe the omics techniques and how omics-based analyses have been applied to investigate and characterize the biological mechanisms of acute-on-chronic liver failure (ACLF) and identify potential predictive biomarkers and therapeutic targets for ACLF.
[Liver International] |
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| Investigators review current research on noncoding RNAs (ncRNAs), consolidate the known roles regulating drug resistance in HCC, and examine the potential clinical applications of ncRNAs in overcoming drug resistance barriers in HCC.
[Journal Of Translational Medicine] |
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| The Innovative Health Initiative has awarded a EUR 24 million grant to the IMAGIO consortium of clinical partners coordinated by Philips, with additional resources and funding from industry partners.
[Philips] |
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| June 26 – 29, 2023
Boston, Massachusetts, United States |
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| | Mount Sinai – New York City, New York, United States |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | Springer Nature Ltd – New York City, New York, United States |
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| | University of Southern Denmark – Odense, Denmark |
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