 | | Vol. 7.22 – 23 June, 2023 |
| |
|
|
| Investigators uncovered a molecular switch facilitating reprogramming between two alternative modes of necroptosis signaling in hepatocytes, fundamentally affecting immune responses and hepatocarcinogenesis.
[Immunity] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists showed that the proteome of fibrolamellar hepatocellular carcinoma (FLC) tumors was distinct from that of adjacent nontransformed tissue. These changes could account for some of the cell biological and pathological alterations in FLC cells, including their drug sensitivity and glycolysis.
[Science Advances] |
|
|
|
| Researchers revealed that the liver-specific putative long non-coding RNA (lncRNA), AC115619, was expressed at low levels in HCC and encoded a micropeptide, designated as AC115619-22aa.
[Cancer Research] |
|
|
|
| The authors investigated whether nonalcoholic fatty liver disease development was controlled by lncRNA growth-arrest specific transcript 5 (GAS5)/miR-28a-5p/membrane associated ring-CH-type finger 7 (MARCH7)-mediated pyroptosis using in vivo and in vitro models.
[Cell Death & Differentiation] |
|
|
|
| Scientists identified that the expression of protein phosphatase magnesium or manganous dependent 1H (PPM1H) mRNA and protein could be inhibited by activating transcription factor 6 (ATF6) in hepatoma cells and mice with liver Atf6-knock-down.
[Molecular Therapy – Nucleic Acids] |
|
|
|
| RNA sequencing was performed on naive CD4+ T cells from normal and ischemia-reperfusion injury model mice to identify relevant transcription factors.
[Cell Death & Disease] |
|
|
|
| Using an aldosterone (Aldo)-continuous pumping rat model, investigators observed that Aldo-induced liver fibrosis and capillarization of liver sinusoidal endothelial cells (LSECs).
[Hepatology International] |
|
|
|
| Scientists performed a prospective cohort study involving 4524 adults within the MJ health check-up cohort. Logistic regression model was used to estimate odds ratios and confidence intervals for subclinical atherosclerosis.
[Liver International] |
|
|
|
| Twenty-eight male Sprague-Dawley rats were randomly divided into four groups: normal control, apocynin (APO), monosodium glutamate (MSG), and MSG + APO. The MSG and MSG + APO groups received 120 mg/kg MSG solution orally for 28 consecutive days.
[Heliyon] |
|
|
|
| Researchers observed significant up-regulation of polypyrimidine tract binding protein 1 (PTBP1) in primary HCC tissues. High levels of PTBP1 expression were associated with poor prognosis and increased metastatic potential in HCC.
[Heliyon] |
|
|
|
|
|
| The authors summarize the role of sphingosine kinase in the course of liver disease and illustrate its effects on both physiological and pathological conditions of the liver.
[Toxicological Research] |
|
|
|
|
| Manchester researchers have been awarded over £1 million by NHS England to explore the use of an innovative test for liver cancer, which will help patients access earlier care and potentially save lives.
[The University of Manchester] |
|
|
|
| Tvardi Therapeutics, Inc. announced that the first patients have been dosed in each arm of its ongoing REVERT LIVER CANCER trial.
[Tvardi] |
|
|
|
|
| September 4 – 7, 2023
Surrey, England, United Kingdom |
|
|
|
|
|
| | Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | Scripps Research – La Jolla, California, United States |
|
|
|
| | University of Southern Denmark – Odense, Denmark |
|
|
|
| | Temple University – Philadelphia, Pennsylvania, United States |
|
|
|
| | Mount Sinai – New York City, New York, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
